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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1984
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: A published study containing sufficient details to regard it as reliable for use in hazard assessment. Only basic experimental detail provided in publication

Data source

Reference
Reference Type:
publication
Title:
Further studies on the toxicology of the glycol ethers with emphasis on rapid screening and hazard assessment
Author:
Doe J.E.
Year:
1984
Bibliographic source:
Environmental Health Perspectives, 57, 199-206

Materials and methods

Principles of method if other than guideline:
Not sufficient information available to determined
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
2-isopropoxyethanol
EC Number:
203-685-6
EC Name:
2-isopropoxyethanol
Cas Number:
109-59-1
Molecular formula:
C5H12O2
IUPAC Name:
Propan-2-ol
Details on test material:
- Name of test material (as cited in study report): ethylene glycol monoisopropyl ether

Test animals

Species:
rat
Strain:
other: Alpk/Ap (Wistar-derived)
Sex:
male

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
whole body
Vehicle:
air
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
4 h
Concentrations:
Saturated vapour: 3500ppm (15mg/l)
No. of animals per sex per dose:
Five
Control animals:
yes

Results and discussion

Effect levelsopen allclose all
Sex:
male
Dose descriptor:
other: NOAEL: Reduction on testis weight
Effect level:
> 3 500 ppm
Based on:
test mat.
Exp. duration:
4 h
Remarks on result:
other: no reduction on testis weight compared to controls was observed at concentration tested
Sex:
male
Dose descriptor:
other: NOAEL
Remarks:
hematuria
Effect level:
< 3 500 ppm
Based on:
test mat.
Exp. duration:
4 h
Sex:
male
Dose descriptor:
LC0
Effect level:
>= 3 500 ppm
Based on:
test mat.
Exp. duration:
4 h
Gross pathology:
Testis weight, % of body weight:
3500ppm EGPE: 0.95 +/-0.09
Control: 0.98 +/-0.10

Applicant's summary and conclusion

Interpretation of results:
other: probably category IV or V
Remarks:
Criteria used for interpretation of results: OECD GHS
Conclusions:
At the concentration tested no animals died and no reduction of testis weight was observed, but hematuria was present.
Executive summary:

In this study male rats were exposed to 2 -isopropoxyethanol at 3500ppm (15mg/l) by inhalation for a period of 4 hours. Following 15 days in observation, the rats were sacrificed and examined. No animals died during this period, and no changes to the testis weight was observed compared to controls. However, haematuria was noted in the animals treated with 2 -isopropoxyethanol.