Registration Dossier
Registration Dossier
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EC number: 203-685-6 | CAS number: 109-59-1
Long-term toxicity to fish
Administrative data
- Endpoint:
- long-term toxicity to fish
- Type of information:
- (Q)SAR
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Modeled result from QSAR model generally regarded as reliable.
Data source
Reference
- Reference Type:
- other: QSAR
- Title:
- ECOSAR v1.11
- Author:
- US EPA
- Year:
- 2 013
- Bibliographic source:
- http://www.epa.gov/oppt/newchems/tools/21ecosar.htm
Materials and methods
Test material
- Reference substance name:
- 2-isopropoxyethanol
- EC Number:
- 203-685-6
- EC Name:
- 2-isopropoxyethanol
- Cas Number:
- 109-59-1
- Molecular formula:
- C5H12O2
- IUPAC Name:
- Propan-2-ol
Constituent 1
Test organisms
- Test organisms (species):
- other: Fish
Results and discussion
Effect concentrations
- Duration:
- 30 d
- Dose descriptor:
- other: ChV value
- Effect conc.:
- 181 mg/L
- Nominal / measured:
- estimated
- Remarks on result:
- other: QSAR. End point reported as ChV
Any other information on results incl. tables
This result can be compared to the predictions for the LC50 values for n-propoxyethanol of 110 mg/l suggesting that the branched isomer is of slightly lower toxicity than the unbranched isomer. This figure is based on a logKow of 0.673.
A QMRF to support the use of this QSAR is attached to this record.
Applicant's summary and conclusion
- Executive summary:
US EPA ECOSAR software (v1.00a) estimates the 30 -day fish ChV for ethoxypropanol to be 181 mg/L, based on structure activity relationship models for neutral organic compounds.
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