Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 203-685-6 | CAS number: 109-59-1
Specific investigations: other studies
Administrative data
Link to relevant study record(s)
Description of key information
Additional information
There is good evidence to show that isopropoxyethanol produces haemolysis in rats. The evidence suggests that humans are more resistant to this effect than rats:
In an inhalation study, isopropoxyethanol was found to cause marked haemolysis in rats. The NOAEL for inhalation exposure was established at 300ppm. A sub-acute study in which rats were repeatedly exposed to isopropoxyethanol using sub-cutaneous doses of 66 and 110mg/kg produced distinct hematological alterations which are typical of hemolytic anemia. There was clear evidence that a resistance to the effect occured with most haematological parameters recovering completely or partially during the study, despite continue exposure to the test substance. In another study, human RBCs were more resistant to the hemolytic activity of the active metabolite propoxyacetic acid than rat erythrocytes.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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