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EC number: 254-179-7 | CAS number: 38888-98-1
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
Available data:
1,1-DPE:
The freshwater algae Selenastrum capricornutum was exposed to 1,1-DPE in a 72-hour test. In this test, WaterSoluble Fractions (WSFs) were used to test effects. The results are expressed in terms of loading rate. The test concentration of 1-Phenylethylbenzene that resulted in 50% inhibition (IL50) was determined to be greater than 100 mg/L. Results presented are based on nominal loading rates. No analytical verification of test substance concentration was possible.As the test substance is only sparingly soluble in water and no dose verification was possible, the study reliability can only be judged as 3.
SAS-296:
Scenedesmus subspicatus was exposed to an aqueous solution of the test material at a concentration of 0.56 mg/l (six replicate flasks) for 72 hours. No analytical verification of test substance concentrations was performed. The 72h-EC50 value was estimated as >0.56 mg/l (nominal).
SAS-296:
Selenastrum capricornutum was exposed to 1,4-dimethyl-2-(1-phenylethyl) for 72 hours. The test was undertaken using a dispersant (HCO-50) at a concentration of 40 mg/L. The toxicity values EC50 based on mean measured concentrations were >1.54 mg/L and 0.93 mg/L, respectively.
QSARs - Data based on calculations using EPI Suite v4.10 (KOCWIN (Molecular Connectivity Method; worst case)/ ECOSAR Program v1.00. ECOSAR is a known and reliable calculation tool for this endpoint and therefore this estimation can be used in a weight-of-evidence approach. For PTE the calculated 72 h EC50 was 0.82 mg/L, for 11-DPE was 1.69 mg/L, for BT was 0.93 mg/L, for SAS-296 was 0.4 mg/L and for SAS-305 was 0.25 mg/L.
Key value for chemical safety assessment
- EC10 or NOEC for freshwater algae:
- 0.56 mg/L
Additional information
In general all members of the diphenylmethane category do have a very similar and obviously unspecific ecotoxicity profile towards the three species from different trophic levels the fact of which proves that they all belong to the same category. Therefore, it is justified to read across the lowest measured value for acute toxicity to algae from SAS-296 to 1,1 -DPE.
The measured EC50 value of > 100 mg/l is considered as not reliable since no analytical verification of doses was possible and a water accomodated fraction was used.
No further testing is required.
For detailed read across rationale and justification see section 13, Read across document.
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