Registration Dossier
Registration Dossier
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EC number: 210-157-9 | CAS number: 608-27-5
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given. No histopathological examination.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
Materials and methods
- Principles of method if other than guideline:
- According to Noakes and Sanderson, 1969: undiluted test substance on the shaved skin for 24 hours, post exposure observation time: 14 days
- GLP compliance:
- no
Test material
- Reference substance name:
- 2,3-dichloroaniline
- EC Number:
- 210-157-9
- EC Name:
- 2,3-dichloroaniline
- Cas Number:
- 608-27-5
- Molecular formula:
- C6H5Cl2N
- IUPAC Name:
- 2,3-dichloroaniline
- Details on test material:
- IUCLID4 Test substance: other TS: 2,3-dichloroaniline, technical pur
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Vehicle:
- other: none
- Doses:
- males: 500, 750, 1000 µl/kg bw; females: 100, 250, 500, 1000 µl/kg bw
- No. of animals per sex per dose:
- 10
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- >= 934 mg/kg bw
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 1 000 mg/kg bw
Any other information on results incl. tables
Clinical signs: reduced general condition, sedation difficulties in breathing, cramps, and inflammation at the injection sides:
dosages in µl/kg bw: number of dead rats / number of rats with clinical signs / number of rats used / time of death:
males: // females:
0100: -------------------- // 0 / 5 / 5 / --
0250: -------------------- // 0 / 5 / 5 / --
0500: 0 / 5 / 5 / -- .. // 0 / 5 / 5 / --
0750: 2 / 10 / 10 / 1d... // ----------------
1000: 6 / 10 / 10 / 5h-2d // 1 / 10 / 10 / 1d
Calculation:
LD50 (males): 934 µl/kg bw
LD50 (females): >1000 µl/kg bw
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
