Registration Dossier
Registration Dossier
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EC number: 210-157-9 | CAS number: 608-27-5
Repeated dose toxicity: dermal
Administrative data
- Endpoint:
- repeated dose toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Original report not available. Individual animal data not shown
Data source
Reference
- Title:
- No information
- Author:
- E.I. Dupond De Nemours & CoSkin Acegenesis (DOW Method) in rabbits with testing material azobenzene and other chemicals, 5/19/78 EPA OTS0514863, EPA/OTS215025
Materials and methods
- Principles of method if other than guideline:
- Method: other: 2 drops were applied with a dropper to the distal half of the inner aspect of the right ear of each of 2 rabbits. After a 2-day rest period after the end of treatment 1 rabbit was sacrificed for histopathological examination.
- GLP compliance:
- no
Test material
- Reference substance name:
- 2,3-dichloroaniline
- EC Number:
- 210-157-9
- EC Name:
- 2,3-dichloroaniline
- Cas Number:
- 608-27-5
- Molecular formula:
- C6H5Cl2N
- IUPAC Name:
- 2,3-dichloroaniline
- Details on test material:
- IUCLID4 Test substance: other TS: 2,3-dichloroaniline purity 99.25%)
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Details on exposure:
- Route of Administration: dermal
- Duration of treatment / exposure:
- 4 weeks
- Frequency of treatment:
- 5 days/week
Doses / concentrations
- Remarks:
- Doses / Concentrations:
2 drops (ca. 0.1 ml), no further information
Basis:
- Details on study design:
- Post-exposure period: 2 days
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
gross examination:
Slight sloughing and slight to moderate hair loss1020 days. no thickening of the ear at 20 days.
Pathological finding:
hair follicles appeared normal; skin covered with white scaley material. not acnegenic
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
