Registration Dossier
Registration Dossier
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EC number: 292-564-1 | CAS number: 90640-45-2
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
The EC50_3h of 20.5 mg/L for microorganisms determined in an OECD209 test with N-C 12-14-alkyl-1,3-diaminopropane (CAS 90640-43-0) was used as a key value for the registered substance Amines, N-C16-22-alkyltrimethylenedi.
Key value for chemical safety assessment
- EC50 for microorganisms:
- 20.5 mg/L
Additional information
Toxicity microorganisms tests are not available for Amines, N-C16 -22 -alkyltrimethylenedi. Based on similarities of the environmental fate properties and the ecotoxicity data obtained in algae, Amines, N-C16 -22 -alkyltrimethylenedi can be grouped with the alkyl 1,3 diaminopropanes into the same category. In order to generate the worst-case scenario, all the OECD 209 tests done with various alkyl chain length diamines were taken into account and the lowest EC50 value was used as a key value for the registered substance Amines, N-C16 -22 -alkyltrimethylenedi.
The toxicity of Amines, N-C12 -18 -alkyltrimethylenedi- to microorganisms was tested according to OECD 209 using activated sludge from a communal waste water treatment plant. The inhibition of the oxygen demand was observed after 3 hours of incubation with the test substance. The EC50 was 30.2 mg/L and the NOEC was 8.7 mg/L.
Two tests according to OECD 209 have been performed with C18 -unsatd-1,3 -diaminopropane (CAS 7173-62-8) to assess the toxicity of activated sludge of a predominantly domestic sewage. EC50_3h of 66.0 mg/L was obtained in the first study (Hoechst, 1992) and EC50 _30min of 25.1 mg/L in the second study (Akzo Nobel, 1995).
In the same conditions, EC50_3h of 219 mg/L was obtained with C16-18 and C18-saturated-1,3-diaminopropane (CAS 133779-11-0) and of 20.5 mg/L for N-C12-14-alkyltrimethylenediamines (CAS No. 90640-43-0) (Noack, 2008a, b).
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