Registration Dossier
Registration Dossier
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EC number: 292-564-1 | CAS number: 90640-45-2
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
Despite the fact that the log Kow was measured for Amines, N-C16-22-alkyltrimethylenedi- applying the most appropriate method according to the REACH guidance i.e. the slow stirring method (OECD 123), there is unfortunately no reliable relationship between the measured log Kow and BCF for this type of substances.
Regarding the diamines category, the worst case predicted BCF value is N-octadecylpropane-1,3-diamine (CAS 4253-76-3) according to BCFBAF predictions. Therefore, this calculation is considered in a worst-case approach to assess the bioaccumulation of the registered substance Amines, N-C16-22-alkyltrimethylenedi-. BCFBAF predictions on the constituent with the highest chain length (N-docosylpropane-1,3-diamine, CAS 15268-40-3) demonstrates that a higher bioaccumulation potential is not expected above C18 diamines.
Although the calculated BCF values predicted by the log Kow value of 7.69 (EPIsuite v4.0) for the unprotonated chemical form is clearly higher than the measured value of 1.5 (OECD 123), preference is given to base the calculated BCF on the measured log Kow value giving a calculated BCF value of 4.6. The calculated BCF value indicates that Amines, N-C16-22-alkyltrimethylenedi- have a low bioaccumulation potential.
The low calculated BCF is considered realistic as the fraction of unprotonated amines will be very low in the environment. The predicted BCF value could even be lower, as the calculation of the BCF is not taking into account metabolism of the compound, e.g. by fish and other aquatic organisms.
Key value for chemical safety assessment
- BCF (aquatic species):
- 4.6 L/kg ww
Additional information
Alkyl-1,3-diaminopropanes are readily biodegradable and it is therefore unlikely that these substances will accumulate in the food chain (BMF<1). Indeed, it can be expected that metabolism will occur in aquatic species like fish, the predicted BCF value could even be lower. In addition, performance of a standard aquatic exposure based OECD 305 test seems technically not feasible with these strongly sorbing easily degradable UVCB substances.
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