Registration Dossier

Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Original reference in foreign language (Czech language) and documentation is insufficient for assessment.

Data source

Reference
Reference Type:
publication
Title:
Phenol metabolism in guinea pigs
Author:
Bardodej Z. and Krivucova M.
Year:
1961
Bibliographic source:
Cslka Hyg., 6(9), 553-554

Materials and methods

Objective of study:
metabolism
Test guideline
Guideline:
other: No data. If any guideline was followed, no details are given.
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
No data
Radiolabelling:
not specified

Test animals

Species:
guinea pig
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
Not known

Administration / exposure

Route of administration:
other: not known
Vehicle:
not specified
Details on exposure:
Not known
Duration and frequency of treatment / exposure:
Not known
Doses / concentrations
Remarks:
Doses / Concentrations:
Not known
No. of animals per sex per dose:
Not known
Control animals:
not specified
Positive control:
Not known
Details on study design:
Not known
Details on dosing and sampling:
METABOLITE CHARACTERISATION STUDIES
- Tissues and body fluids sampled: urine
- No other information
Statistics:
Not known

Results and discussion

Preliminary studies:
Not applicable

Toxicokinetic / pharmacokinetic studies

Details on absorption:
Not applicable
Details on distribution in tissues:
Not applicable
Details on excretion:
Not applicable

Metabolite characterisation studies

Metabolites identified:
yes
Details on metabolites:
Veratrole was demethylated to 2-methoxyphenol. From a Table presented in this Czech paper it is only possible to guess that the percentage of the administered dose that is metabolised to 2-methoxyphenol is between 6 and 22%.

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): bioaccumulation potential cannot be judged based on study results