Registration Dossier

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
disregarded due to major methodological deficiencies
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Secondary literature. Original reference in Russian. Documentation insufficient for assessment.

Data source

Reference
Reference Type:
publication
Title:
Toxicity of 1,2-dimethoxybenzene Gigiena Truda i Professional'nye Zabolevaniya.
Author:
Grodetskaia, V.S., Drobyshevskaia, G.L., and Kondaurova, G.L.
Year:
1982
Bibliographic source:
Labor Hygiene and Occupational Diseases. Vol. 26(2), Pg. 54. (Reference: Information from the Soviet Toxicology Centre 613.632.547.52/59)

Materials and methods

Principles of method if other than guideline:
no data
GLP compliance:
no
Test type:
other: no data

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
not specified
Details on test material:
no data

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
No data

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Details on dermal exposure:
No data
Duration of exposure:
No data
Doses:
0.25 and 1.25 g/kg bw
No. of animals per sex per dose:
No data
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
700 - 890 mg/kg bw
Based on:
test mat.
Remarks on result:
other: No mortality occurred at a dose level of 25 mg/kg and 100% mortality was observed at 1250 mg/kg. The LD50 was calculated as 700 or 890 mg/kg.

Applicant's summary and conclusion

Interpretation of results:
harmful
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Veratrole is harmful in contact with skin.