Registration Dossier

Administrative data

Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
From 26 april 2012 to 12 october 2012
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP study, OECD 104 compliant.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2012
Report Date:
2012

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.4 (Vapour Pressure)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Remarks:
11 april 2011
Type of method:
static method

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: crystalline

Results and discussion

Vapour pressureopen allclose all
Temp.:
20 °C
Vapour pressure:
73 Pa
Temp.:
25 °C
Vapour pressure:
96 Pa

Any other information on results incl. tables

Measurement Values Vapour Pressure Determination

 

1. Determination
increasing temperature

2. Determination
decreasing temperature

Temp. in °C

Pressure in mbar

Temp. in °C

Pressure in mbar

20.0

0.8

54.7

4.2

30.2

1.2

45.6

2.8

40.3

2.1

35.6

1.7

50.0

3.3

24.9

1.0

62.0

5.8

14.6

0.5

 

From the measured values for the increasing and for the decreasing temperature, log P (in log Pa) and 1/T (in 1/K) were calculated. The measured and the calculated values were plotted (p against T and log P against 1/T).

The regression curve with slope B. intercept A and correlation r was calculated (graph log P vs. 1/T). From the values of these parameters, vapour pressures at 20.0 and at 25.0 °C were calculated using the following equation:

logP = B*(1/T)+A => P(20°C)= 10E(B*(1/293.15)+A) and P(25°C)= 10E(B*(1/298.15)+A)

The calculation results are presented in the following table:

Calculated values for 1/T and log (P)

n

Temperature T

Pressure P

Temperature T

1/T

log P

 

°C

mbar = hPa

K

1/K

log Pa

1

20.0

0.8

293.15

0.00341122

1.9031

2

30.2

1.2

303.35

0.00329652

2.0792

3

40.3

2.1

313.45

0.00319030

2.3222

4

50.0

3.3

323.15

0.00309454

2.5185

5

62.0

5.8

335.15

0.00298374

2.7634

6

54.7

4.2

327.85

0.00305018

2.6232

7

45.6

2.8

318.75

0.00313725

2.4472

8

35.6

1.7

308.75

0.00323887

2.2304

9

24.9

1.0

298.05

0.00335514

2.0000

10

14.6

0.5

287.75

0.00347524

1.6990

 

Calculated Values for vapour pressure

Parameter

Value

Unit

Vapour Pressure (20 °C)

73

Pa

Vapour Pressure (25 °C)

96

Pa

 

Applicant's summary and conclusion

Conclusions:
The vapour pressure of Veratrole was 73 Pa at 20°C and 96 Pa at 25°C.
Executive summary:

In a study (Henke W, 2012), the vapour pressure of Veratrole was determined using the static method and following the OECD guideline 104, under GLP conditions.

The vapour pressure of Veratrole was 73 Pa at 20°C and 96 Pa at 25°C, showing a low volatility.