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Physical & Chemical properties

Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
The 22th of July, 2013
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: The study was conducted in OECD 107 "Partition Coefficient (n-octanol/water): Shake Flask Method " adopted 27.07.95.Test conducted according to internationally accepted testing guidelines.
Qualifier:
according to guideline
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
Version / remarks:
adopted 27.07.95
GLP compliance:
no
Type of method:
shake-flask method to: flask method
Partition coefficient type:
octanol-water
Analytical method:
photometric method
Type:
Pow
Partition coefficient:
0.032
Temp.:
20 °C
pH:
6.59
Type:
log Pow
Partition coefficient:
-1.569
Temp.:
20 °C
pH:
6.59
Details on results:
A first scan of the solutions was performed in the range 190 – 800 nm to choose the best wavelength peak for the quantitative measurements. In the case of Reactive Red 141: lambda= 288.50 nm.Concentration of the n-octanol phase was high: so 2 ml of extract from the n-octanol phase was dissolved in a 10 ml volumetric flask with n-octanol saturated with water solution, and measured in the range 205 – 800 nm. n-octanol phase curves showed shape variations respect to aqueous phases probably due to bathochromic shift. Concentration was deduced by difference of absorbance between reference and aqueous phase absorbance values.
Conclusions:
The average Pow measured is 0.032220 at pH of 6.59, the average log Pow measured is - 1.5691.
Executive summary:

Partition coefficient was determined by OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method), adopted 27.05.95.

n-octanol and double distilled water were pre saturated: enough quantity of double distilled water was mixed with n-octanol at room temperature and kept under agitation during 24 hours, then allowing phase separation. Analogous procedure was followed for n-octanol with addition of double distilled water.

The average Pow measured is 0.03220 at pH of 6.59, the average log Pow measured is - 1.5691 at 20 °C.

Description of key information

 Pow = 0.03220 at pH of 6.59;
 log Pow = -1.5691 (average of measurements)

Key value for chemical safety assessment

Log Kow (Log Pow):
-1.569
at the temperature of:
20 °C

Additional information

Partition coefficient was determined by OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method), adopted 27.05.95.

n-octanol and double distilled water were pre saturated: enough quantity of double distilled water was mixed with n-octanol at room temperature and kept under agitation during 24 hours, then allowing phase separation. Analogous procedure was followed for n-octanol with addition of double distilled water.

Approximately exactly 0.04 g test sample was weighed and dissolved with double distilled water saturated in n-octanol to 100 ml in a volumetric flask (mother solution). pH was recorded.

The average Pow measured is 0.03220 at pH of 6.59, the average log Pow measured is - 1.5691 at 20°C (average of measurements).