Zeolite, silica and titanium based, crystalline, synthetic, non fibrous

Acute Toxicity: other routes

Administrative data

Endpoint:

acute toxicity: other routes

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

other information

Reliability:

3 (not reliable)

Rationale for reliability incl. deficiencies:

other: see 'Remark'

Remarks:

Documentation insufficient for assessment: reported data are incomplete and partly inconsistent; only limited data about the test substance is given. A non-guideline method was used and the way the dose is calculated for LD50 purposes is questionable.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1975

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: Huntingdon Research Center

GLP compliance:

no

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Automatically generated during migration to IUCLID 6, no data available

IUPAC Name:

Automatically generated during migration to IUCLID 6, no data available

Details on test material:

UDL-738 (aluminosilicate); UDL-739 Model Product (P & G Code)

Test animals

Species:

rat

Strain:

other: Sprague-Dawley derived

Sex:

male

Administration / exposure

Route of administration:

other: intratracheal

Vehicle:

water

Details on exposure:

The test substance was applied once as aqueous suspension at concentrations of:
10, 25, 50, 100, and 300 mg/mL (UDL-738)
3, 10, 25, 50, and 100 mg/mL (UDL-739)
by intratracheal injection of 1 mL.

Doses:

10, 25, 50, 100, and 300 mg/mL (UDL-738)
3, 10, 25, 50, and 100 mg/mL (UDL-739)

No. of animals per sex per dose:

10

Control animals:

no

Details on study design:

The observation period was 14 days.

Statistics:

LD50-values were calculated from the applied doses using a body weight of 250 g, i.e. the doses expressed in mg/kg are by a factor of 4 higher than the doses given as mg/ml per animal.

Results and discussion

Effect levels

Sex:

male

Dose descriptor:

LD50

Effect level:

ca. 12 - 40 mg/kg bw

Mortality:

UDL-738:
Up to and including a dose of 25 mg/mL one animal died per test group (1/10). At a dose of 50 mg/mL 4/10 animals died during the observation period. Mortality decreased at an increased dose of 100 mg/mL (2/10). None of the animals survived at an application dose of 300 mg/L (10/10). Due to the lack of a dose-concentration ship, the LD50 for UDL-738 is not further specified.

UDL-739:
All of the animals dosed with 3 mg/mL survived (10/10); only one (1/10) exhibited incidence of lung gross abnormalities. Weight gain in this group was normal compared to untreated controls. In the group dosed with 10 mg/mL 9/10 animals died within the 14 days. At the higher doses all (10/10) animals died during the experiment.

Body weight:

UDL-739:
All of the animals dosed with 3 mg/mL survived (10/10); only one (1/10) exhibited incidence of lung gross abnormalities. Weight gain in this group was normal compared to untreated controls. In the group dosed with 10 mg/mL 9/10 animals died within the 14 days. At the higher doses all (10/10) animals died during the experiment.

Gross pathology:

UDL-739:
All of the animals dosed with 3 mg/mL survived (10/10); only one (1/10) exhibited incidence of lung gross abnormalities. Weight gain in this group was normal compared to untreated controls. In the group dosed with 10 mg/mL 9/10 animals died within the 14 days. At the higher doses all (10/10) animals died during the experiment.