Registration Dossier
Registration Dossier
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EC number: 403-080-9 | CAS number: 92484-48-5 BENZTRIAZOL UV ABSORBER BUK 4499; BUK 4499; UV ABSORBER BUK 4499
Endpoint summary
Administrative data
Description of key information
Sodium 3(2H-benzotriazol-2-yl)-5-sec-butyl-4-hydroxybenzenesulfonate was tested for acute toxicity by oral and dermal application to the rat according to OECD guideline 401 and 402. The LD50 (oral) was greater than 5000 mg/kg bw and the LD50 (dermal) was greater than 2000 mg/kg bw.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
Acute toxicity oral:
The test article sodium 3(2H-benzotriazol-2-yl)-5-sec-butyl-4-hydroxybenzenesulfonate was administered to rats of both sexes by oral gavage, at a dose of 5000 mg/kg according to OECD giudeline 401.
The following death rate was observed: 10 % at 5000 mg/kg.
The acute oral LD50 of test item in 10 rats (5 males/5 females) of both sexes, observed over a period of 15 days, was estimated to be greater than 5000 mg/kg.
Acute toxicity dermal:
The test article sodium 3(2H-benzotriazol-2-yl)-5-sec-butyl-4-hydroxybenzenesulfonate was applied to the skin of rats of both sexes by oral gavage for 24 hours at a dose of 2000 mg/kg according to OECD giudeline 402.
The following death rate was observed: 0 % at 2000 mg/kg.
Therefore, the LD50 of test item was estimated to be greater than 2000 mg/kg.
Justification for classification or non-classification
Based on all available information, the test substance is not classified with regard to acute toxicity according to Directive 67/548/EEC (DSD) and to Regulation (EC) No 1272/2008 (CLP), respectively.
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