Registration Dossier
Registration Dossier
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EC number: 200-795-6 | CAS number: 73-22-3
Toxicity to reproduction
Administrative data
- Endpoint:
- screening for reproductive / developmental toxicity
- Remarks:
- based on test type (migrated information)
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1979
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Insufficient information for assessment (only abstract available)
Data source
Reference
- Reference Type:
- publication
- Title:
- Stimulatory Capability of Amino Acids and Dipeptides in Reproduction
- Author:
- Pitkow HS & Davis RH
- Year:
- 1 979
- Bibliographic source:
- Biology of Reproduction, Suppl. 20, 133A
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- 6 subcutaneous injections over 3 days
- GLP compliance:
- no
Test material
- Reference substance name:
- L-tryptophan
- EC Number:
- 200-795-6
- EC Name:
- L-tryptophan
- Cas Number:
- 73-22-3
- Molecular formula:
- C11H12N2O2
- IUPAC Name:
- L-tryptophan
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- Swiss Webster
- Sex:
- female
Administration / exposure
- Route of administration:
- subcutaneous
- Vehicle:
- physiological saline
- Duration of treatment / exposure:
- 3 days
- Frequency of treatment:
- day 1: 3 times; day 2: 2 times; day 3: 1 time
Doses / concentrations
- Remarks:
- Doses / Concentrations:
150 mg/kg bw
Basis:
- No. of animals per sex per dose:
- 12
- Control animals:
- yes, concurrent vehicle
- Details on study design:
- Immature female Swiss Webster mice (9-12 g; 12 animals/group) were given 6 subcutaneous injections within 3 days. All animals were autopsied on day 5. The ovaries and uteri were dissected free of fat and weighed to the nearest tenth of a mg with the uteri pressed onto filter paper to remove excess water.
Results and discussion
Overall reproductive toxicity
- Reproductive effects observed:
- not specified
Any other information on results incl. tables
When compared with saline injected controls, ovarian and uterine weights of L-tryptophan injected mice were significantly higher (P < 0.001). In immature animals given 30 IU of PMS followed by an injection of 5 IU of HCG 56 hours later on day three, a significant increase in ovarian weight by L-tryptophan was seen. No teratogenicity was found.
Applicant's summary and conclusion
- Conclusions:
- The administration of tryptophan caused a gonadotropic effect in dosed mice as the weights of ovaries and uteri were significantly increased. The dosing gave no indications for a teratogenic potential.
As only an abstract is available, these data cannot be finally evaluated.
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