Aluminum antimony nickel silicon titanium vanadium oxide

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

2010

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: Experiment was conducted under conditions comparable to GLP and according to accepted scientific standards

Data source

Reference

Reference 1

Reference Type:

study report

Title:

Unnamed

Year:

2010

Report date:

2010

Reference 2

Reference Type:

study report

Title:

Unnamed

Year:

2010

Report date:

2010

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

OECD Guideline 403 (Acute Inhalation Toxicity)

Deviations:

yes

Remarks:

The in-vivo part of the experiment was not commenced because a respirable test atmosphere could not be generated.

Test guideline 2

Qualifier:

according to guideline

Guideline:

EU Method B.2 (Acute Toxicity (Inhalation))

Deviations:

yes

Remarks:

The in-vivo part of the experiment was not commenced because a respirable test atmosphere could not be generated.

GLP compliance:

no

Remarks:

GLP is not mandatory for the preliminary experiment not involving vertebrate testing

Test type:

other: preliminary experiment for dust generation

Test material

Test material information

Constituent 1

Reference substance name:

silicon(4+) dialuminium(3+) antimony nickel vanadium pentaoxidandiide

EC Number:

931-210-9

Cas Number:

1266534-73-9

Molecular formula:

(M2/nO*Al2O3*ySiO2*wH2O)x*(Ti,Sb,Ni,V O2)z*(Al2O3)k*(Al2Si2O7)l n is the valency of the cation M, predominantly Na, and for Na is n=1; y can range from 2 to 222; w can range from 0 to 30; x can range from 0.2 to 0.7; z can range from 0.01 to 0.05; k can range from 0.03 to 0.39; l can range from 0.26 to 0.39

IUPAC Name:

silicon(4+) dialuminium(3+) antimony nickel vanadium pentaoxidandiide

Details on test material:

- Name of test material (as cited in study report): "LOOP"
- Chemical name: Aluminium silicate and titanium oxide matrix doted with vanadium, nickel, and antimony
- Structural formula attached as image file (if other than submission substance): see Fig.
- Physical state: Dark grey solid.
- Analytical purity: 99%
- Composition of test material, percentage of components: Reaction product from a chemical conversion contains Zeolite and Rutil.
- Lot/batch No.: 09303322/1
- Expiration date of the lot/batch: 29 June 2011
- Stability under test conditions: stable
- Storage condition of test material: Room temperature

Administration / exposure

Vehicle:

air

Analytical verification of test atmosphere concentrations:

no

Remarks:

only particle size distributions

Concentrations:

0.2-0.3 mg/L

Results and discussion

Any other information on results incl. tables

It was not possible to produce a respirable dust atmosphere from the test material in a meaningful concentration. Since this precludes conducting a valid and guideline-compliant experiment, the animal experiment was not performed.

Applicant's summary and conclusion

Conclusions:

The preliminary experiments demonstrated that respirable dust in noteworthy concentrations of "LOOP" cannot be generated using state-of-the-art methodology, even if the product is ground and sieved.
The failed attempts to generate a sufficiently respirable test atmosphere demonstrate that the inherent potential of "LOOP" for alveolar exposure is negligible under foreseeable handling conditions.
From the chemical nature of the test substance - an insoluble mineral mainly consisting of aluminium silicate with smooth shaped particles - a significant inhalation toxicity can be excluded. Performing an inhalation toxicity study according to OECD guideline 403 with the attainable low dust concentrations will therefore bring no additional useful data.