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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Toxicity to aquatic algae and cyanobacteria

Administrative data

Endpoint:
toxicity to aquatic algae and cyanobacteria
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
2013
Report date:
2013

Materials and methods

Principles of method if other than guideline:
ECOSAR v1.11
QMRF and QPRF are attached in IUCLID
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Perfluoroethane
EC Number:
200-939-8
EC Name:
Perfluoroethane
Cas Number:
76-16-4
Molecular formula:
C2F6
IUPAC Name:
hexafluoroethane

Test organisms

Test organisms (species):
other: Green Algae

Results and discussion

Effect concentrations
Duration:
96 h
Dose descriptor:
EC50
Effect conc.:
37.5 mg/L
Nominal / measured:
estimated
Conc. based on:
not specified
Basis for effect:
not specified

Applicant's summary and conclusion

Validity criteria fulfilled:
yes
Conclusions:
The study and the conclusions which are drawn from it fulfil the quality criteria (validity, reliability, repeatability).

ECOSAR modelled LC50 = 37.5 mg/L (conservative estimate based on the estimated LogKow 2.15 and measured water solubility of 520 mg/L).

Executive summary:

The results were predicted with the ECOSAR v1.11. Both a model validation and a judgment of the reliability of the predictions based on the chemical domain were performed. LC50 was modelled to be 37.5 mg/L using the estimated KOWWIN LogKow of 2.15 (see associated QPRF) and measured water solubility of 520 mg/L.

A LC50 was also predicted using an experimental LogKow of 2.0 (reported within the Epiwin software). The predicted LC50 was 47.9 mg/L, which is of the same order of magnitude as that derived with the estimated LogKow. The more conservative estimate based on the estimated LogKow is reported herein.