Registration Dossier

Administrative data

Endpoint:
short-term toxicity to fish
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
The scientific validity of the (Q)SAR model has been established in accordance with the OECD Principles for (Q)SAR Model Validation. This study was selected as the key study because the information provided for the hazard endpoint is sufficient for the purpose of classification and labelling and/or risk assessment.
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
2013
Report Date:
2013

Materials and methods

Principles of method if other than guideline:
ECOSAR v1.11
QMRF and QPRF are attached in IUCLID
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test organisms

Test organisms (species):
Pimephales promelas

Results and discussion

Effect concentrations
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
82.3 mg/L
Nominal / measured:
estimated

Applicant's summary and conclusion

Validity criteria fulfilled:
yes
Conclusions:
The study and the conclusions which are drawn from it fulfil the quality criteria (validity, reliability, repeatability).

ECOSAR modelled LC50 = 82.3 mg/L (conservative estimate based on the estimated LogKow 2.15 and measured water solubility of 520 mg/L).
Executive summary:

The results were predicted with the ECOSAR v1.11. Both a model validation and a judgment of the reliability of the predictions based on the chemical domain were performed. The LC50 was modelled to be 82.3 mg/L using the estimated KOWWIN LogKow of 2.15 and measured water solubility of 520 mg/L. A LC50 was also predicted using an experimental LogKow of 2.0 (reported within the Epiwin software). The predicted LC50 was 113.4 mg/L, which is of the same order of magnitude as that derived with the estimated LogKow. The more conservative estimate based on the estimated LogKow is reported herein.