Reaction product of saturated palm kernel fatty acids and oxybispropanediol

Long-term toxicity to fish

Administrative data

Endpoint:

fish early-life stage toxicity

Type of information:

other: Weight-of-evidence

Adequacy of study:

weight of evidence

Study period:

2018

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Weight of evidence assessment based on structural analogue

Justification for type of information:

No data is available for "Reaction product of saturated palm kernel fatty acids and oxybispropanediol". The properties of this substance is therefore assessed in a weight of evidence analysis based on existing data on a group of similar compounds. See the attached report.

The following type of substances were included in the assessments: other glycerol esters (both data and QSAR), glycerols, fatty acids and alcohol ethoxylates. The main data sources were: NICNAS, Danish EPA QSAR, the HERA reports for alcohol ethoxylates and fatty acids.

Data source

Reference

Reference Type:

other company data

Title:

Unnamed

Year:

2018

Report date:

2018

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Data is based on a weight-of-evidence approach

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Reaction product of saturated palm kernel fatty acids and oxybispropanediol

EC Number:

947-750-3

Molecular formula:

mainly C12 fatty acid but also containing C10, C12, C14, C16 and C18 fatty acids

IUPAC Name:

Reaction product of saturated palm kernel fatty acids and oxybispropanediol

Test material form:

other: Paste

Details on test material:

Same ID as the registered substance

Test organisms

Test organisms (species):

Pimephales promelas

Results and discussion

Effect concentrations

Key result

Duration:

28 d

Dose descriptor:

EC10

Effect conc.:

>= 0.213 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

other: Survival

Remarks on result:

other: See WoE document for details

Applicant's summary and conclusion

Validity criteria fulfilled:

not applicable

Conclusions:

As a conservative approach, the conclusion of the weight-of-evidence approach is based on lowest long-term EC10/NOEC for fish of the AE, leading to the value: Long-term toxicity to fish: EC10≥0.213 mg/L.

Executive summary:

“Reaction product of saturated palm kernel fatty acids and oxybispropanediol” is an UVCB substance. Data on long-term toxicity are based on the relevant substance group, Alcohol Ethoxylates (AE)

As a conservative approach, the conclusion of the weight-of-evidence approach is based on lowest long-term EC10/NOEC for fish of the AE, leading to the value: Long-term toxicity to fish: EC10≥0.213 mg/L.