Registration Dossier
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EC number: 244-870-1 | CAS number: 22252-43-3
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 25 January 2010 – 01 April 2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: This study has been performed according to OECD and EC guidelines and according to GLP principles.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
Test material
- Reference substance name:
- (6R-trans)-7-amino-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
- EC Number:
- 244-870-1
- EC Name:
- (6R-trans)-7-amino-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
- Cas Number:
- 22252-43-3
- Molecular formula:
- C8H10N2O3S
- IUPAC Name:
- 7-amino-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
- Details on test material:
- - Name of test material (as cited in study report): 7-ADCA
- Molecular formula: C8H10N2O3S
- Molecular weight: 214.2
- Substance type: White powder
- Physical state: solid
- Analytical purity: 99.0%
- Impurities: -
- Isomers composition: -
- Purity test date: -
- Lot/batch No: D212013
- Expiration date of the lot/batch: 28 February 2011 (retest date)
- Stability under test conditions: Stable
- Storage condition of test material: In refrigerator (2-8°C) in the dark
- Other: Test substance handling: -
Constituent 1
Results and discussion
Water solubility
- Water solubility:
- 0.193 g/L
- Temp.:
- 20 °C
- pH:
- 4.1
- Details on results:
- The results for the samples taken at 24, 48 and 72 hours are given in Table.
The maximum difference (MD) of the concentrations determined in the 24, 48 and 72 hour test samples was < 15%. According to the guidelines, the water solubility of the test substance is given as the mean value of the analysed concentrations.
No test substance was detected in the pretreated samples from the blank water mixture.
Any other information on results incl. tables
Stirring time |
Analysed concentration |
Mean |
MD |
pH |
|
|
|
|
|
24 |
0.191 |
0.193 |
3.2 |
4.1 |
|
|
|
|
|
48 |
0.197 |
|
|
4.1 |
|
|
|
|
|
72 |
0.193 |
|
|
4.1 |
|
|
|
|
|
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): moderately soluble (100-1000 mg/L)
The flask method was chosen for the determination of the water solubility of 7-ADCA. The water solubility of the test substance at 20°C was 0.193 g/l. The pH of the aqueous samples after 72 hours of stirring was 4.1.
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