Registration Dossier
Registration Dossier
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EC number: 200-816-9 | CAS number: 74-86-2
Toxicological Summary
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - workers
Acetylene is a simple asphyxiant. No evidence of systemic toxicity were seen in humans following acute inhalation exposure up to one hour to concentrations up to 100,000 ppm (107,000 mg/m3), the only symptom being a feeling of mild intoxication (Davidson, 1925). Furthermore there was no indication of any local irritant effects. Acetylene does not present an acute hazard following inhalation and is not classified under CLP, hence there is no requirement to propose an acute DNEL.
Chronic exposure of rats and mice to acetylene at 20 ppm (21.4 mg/m3) for 18 and 12 months respectively had no effect on survival and no evidence of carcinogenicity. Acetylene was tested as a control in that study because it was use as stabilizing agent for the test substance. Therefore the study is not adequate for DNEL derivation but gives a weight of evidence that no chronic effect is to be expected from low concentrations of acetylene.
There is no evidence of irritation following acute exposure, and indeed the use of acetylene as an asphyxiant supports this, thus there is no proposal for a short-term DNEL, nor DNEL for systemic effects.
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - General Population
Acetylene is a simple asphyxiant. No evidence of systemic toxicity were seen in humans following acute inhalation exposure up to one hour to concentrations up to 100,000 ppm (107,000 mg/m3), the only symptom being a feeling of mild intoxication (Davidson, 1925). Furthermore there was no indication of any local irritant effects. Acetylene does not present an acute hazard following inhalation and is not classified under CLP, hence there is no requirement to propose an acute DNEL.
Chronic exposure of rats and mice to acetylene at 20 ppm (21.4 mg/m3) for 18 and 12 months respectively had no effect on survival and no evidence of carcinogenicity. Acetylene was tested as a control in that study because it was use as stabilizing agent for the test substance. Therefore the study is not adequate for DNEL derivation but gives a weight of evidence that no chronic effect is to be expected from low concentrations of acetylene.
There is no evidence of irritation following acute exposure, and indeed the use of acetylene as an asphyxiant supports this, thus there is no proposal for a short-term DNEL, nor DNEL for systemic effects.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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