Registration Dossier
Registration Dossier
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EC number: 244-256-3 | CAS number: 21178-63-2
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
In Vitro:
The test item chromium trioleat was tested for its mutagenic potential in Salmonella typhimurium and Escherichia coli, in the standard plate test (SPT) and the preincubation test (PIT), according to the OECD TG 471. The tester strains were: TA1535, TA100, TA1537, TA98 and E. coli WP2 uvrA. Testing was done in absence and presence of S9 mix. Negative and positive controls were included.The test concentrations were as follows:
- SPT (all strains, with and without S-9 mix): 16.8 - 4200 µg/plate
- PIT (all strains, with and without S-9 mix): 14.0 - 3500 µg/plate
When tested in all strains mentioned above under SPT and PIT conditions, with and without S9 mix, the test item did not induce an increase in his+ or trp+ revertant colonies at concentrations up to 4200 µg/plate. A weak bacteriotoxic effect was observed under all test conditions. Precipitation of the test substance was found from about 350 µg/plate onward. Referring to controls, the results of the negative as well as the positive controls performed in parallel corroborated the validity of this study, since the values fulfilled the acceptance criteria of this study. Thus, under the experimental conditions chosen, the test item is not mutagenic in the Ames-test.
Short description of key information:
Ames-Test: not mutagenic (BASF AG, 2002)
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
The test item was tested for bacterial mutagenicity according to the OECD TG 471. Because of negative results, there is no need to classify the test item for mutagenicity according to the EU Directive 67/548/EC and according to the CLP Regulation 1272/2008.
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