Registration Dossier
Registration Dossier
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EC number: 244-256-3 | CAS number: 21178-63-2
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: well-documented, non-GLP but guideline-conform study report
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Limit test:
- yes
Test material
- Reference substance name:
- Chromium trioleate
- EC Number:
- 244-256-3
- EC Name:
- Chromium trioleate
- Cas Number:
- 21178-63-2
- Molecular formula:
- C18 H34 O2 .1/3 Cr
- IUPAC Name:
- chromium(3+) tris((9Z)-octadec-9-enoate)
- Details on test material:
- Name of the test substance used in the study report: Chrom(III)-Oleat
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- 5 animals per cage (type: stainless steel wire mesh with no bedding); animal identification via cage cards. The rats were housed in fully air-conditioned rooms with a temperature ranging from 20 - 24°C and a relative humidity of 30 - 70%. The day/night rhythm was 12 h dark and 12 h light. A standardized laboratory diet as well as tap water were available ad libitum. Young adult rats of a comparable weight were used.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- olive oil
- Details on oral exposure:
- The test substance was insoluble in water. The test substance was administered as a solution.
- Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: several times on the day of administration (at least once each working day)
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- none
- Clinical signs:
- other: none
- Gross pathology:
- No pathologic findings noted.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
