1H-Pyrazolo[3,4-c]pyridine-3-carboxylic acid, 4,5,6,7-tetrahydro-1-(4-methoxyphenyl)-6-(4-nitrophenyl)-7-oxo-, ethyl ester

Explosiveness

Link to relevant study record(s)

Reference

Endpoint:

explosiveness

Type of information:

experimental study

Adequacy of study:

key study

Study period:

May 2014

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Study conducted to standard UN test guidelines, with possible minor methodological deficiencies, which do not effect the quality of the relevant results

Qualifier:

according to guideline

Guideline:

other: UN Recommendations on the Transport of Dangerous Goods, Manual of Tests and Criteria, Fifth revised edition, 2009: Explosives; Series 1 type (b): Koenen Test

Deviations:

yes

Remarks:

2.0 mm orifcace plate used only

GLP compliance:

not specified

Parameter:

thermal sensitivity - Koenen test: diameter of the orifice plate

Remarks on result:

not thermal sensitive if heated under defined confinement

The test results are summarized in the table below. The reactions are characterized in the UN Manual of Tests and Criteria as effect type “O” (i.e. tube unchanged), which is categorized as “no explosion” (considered negative). Each trial produced a flame out of the top of the orifice (approximately 2 feet) that had a burn time of roughly 40 seconds for each trial.

Summary of Koenen Test Results

Item	Sample	Conditions and Results
0	Dibutyl phthalate	1.5-mm orifice: Heating rate of 3.3°C/sec ± 0.3°C, Koenen apparatus within calibration
1	BMS-589152-01 – Trial 1	2.0-mm orifice; 3.3°C/sec ± 0.3°C; Effect type “O” (i.e. tube unchanged); 5-minute test duration
2	BMS-589152-01 – Trial 2	2.0-mm orifice; 3.3°C/sec ± 0.3°C; Effect type “O” (i.e. tube unchanged); 5-minute test duration
3	BMS-589152-01 – Trial 3	2.0-mm orifice; 3.3°C/sec ± 0.3°C; Effect type “O” (i.e. tube unchanged); 5-minute test duration

Interpretation of results:

non explosive

Conclusions:

Based on the test results of a limiting diameter of 2.0 mm, BMS-589152-01 sample shows no violent effect on heating under confinement.

Description of key information

Testing on the sample BMS-589152-01 was conducted to characterize its sensitiveness to the effect of intense heat under high confinement using the Koenen test

Based on the test results, sample BMS-589152-01 has shown to have no violent effect on heating under confinement since the limiting diameter is 2.0 mm or less.

Key value for chemical safety assessment

Explosiveness:

non explosive