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Physical & Chemical properties

Vapour pressure

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Administrative data

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
25 to 28 Jun 2019
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
equivalent or similar to guideline
Guideline:
EU Method A.4 (Vapour Pressure)
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
GLP compliance:
yes (incl. QA statement)
Remarks:
Medicines & Healthcare products Regulatory Agency (MHRA)
Type of method:
effusion method: vapour pressure balance
Key result
Temp.:
25 °C
Vapour pressure:
0.008 Pa

Results

Recorded temperatures, mass differences and the resulting calculated values of vapor pressure were converted in graphs. The vapour pressure values at 25 °C, which were extrapolated from each graph, are shown in the following table.

Summary of Vapour Pressure Data

Run

Log10 [ Vp (25 °C) ]

2

-2.06

3

-2.07

4

-2.14

5

-2.06

7

-2.09

8

-2.04

9

-2.08

10

-2.10

Mean

-2.08

Vapour pressure

8.35E-03 Pa

 

Discussion

The test item did not change in appearance under the conditions used in the determination.

Testing was performed over the relatively low temperature range of 30 °C to 40 °C due to the test item blocking the shutter mechanism at higher temperatures. The nature of the plots obtained is directly related to this use of low temperature, however, the plots are deemed suitable for use.

The results may represent rounded values obtained by calculations based on the exact raw data.

Conclusion

The vapor pressure of the test item has been determined to be 8.35E-03 Pa at 25 °C.

Description of key information

1,3-bis(trimethylsilyl)urea: 8.35E-03 Pa at 25 °C (OECD 104, vapour pressure value)

Key value for chemical safety assessment

Vapour pressure:
0.008 Pa
at the temperature of:
25 °C

Additional information