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Diss Factsheets

Physical & Chemical properties

Density

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Reference
Endpoint:
relative density
Type of information:
experimental study
Adequacy of study:
key study
Study period:
22 Jul to 20 Dec 2019
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 109 (Density of Liquids and Solids)
Qualifier:
according to guideline
Guideline:
EU Method A.3 (Relative Density)
GLP compliance:
yes (incl. QA statement)
Remarks:
Medicines & Healthcare products Regulatory Agency (MHRA)
Type of method:
pycnometer method
Type:
relative density
Density:
0.983 other: Relative density is dimensionless
Temp.:
20 °C
Type:
density
Density:
983 kg/m³
Temp.:
20 °C

Results

Calibration

The pressure readings and the calculated volume for the reference and sample cells are shown in the following table:

Determination

P1

(psig)

P2

(psig)

P3

(psig)

P4

(psig)

Reference cell volume (cm3)

Sample cell volume (cm3)

1

17.161

6.495

17.252

8.543

90.821

149.144

2

17.087

6.481

17.664

8.752

91.491

149.722

3

17.513

6.639

17.766

8.801

91.333

149.594

 

Mean reference cell volume: 91.215 cm3

Mean sample cell volume: 149.487 cm3

As the reference cell volume and sample cell volume were within the defined tolerance (90.953 ± 1.0 cm3 and 149.225 ± 1.0 cm3 for the reference and sample cell volumes respectively), the gas comparison pycnometer was therefore considered acceptable for use.

Sample

The pressure readings, calculated volumes and density values obtained for the test item are shown in the following table:

Determination

Replicate

P1 (sample)

(psig)

P2 (sample)

(psig)

Volume

(cm3)

Density

(kg/m3)

Mean density

(kg/m3)

1

A

17.212

7.186

22.2

993

987

B

17.320

7.238

22.4

984

C

17.536

7.327

22.4

985

2

A

17.194

7.086

19.4

992

979

B

17.177

7.090

19.7

974

C

17.174

7.091

19.8

971

 

Mean density: 983 kg/m3

Relative density: 0.983

Temperature: 20.0 ± 0.5 °C

 

Discussion

Duplicate determinations were performed to ensure a reproducibility of less than ± 20 kg/m3 was obtained.

 

Conclusion

The density of the test item has been determined to be 983 kg/m3 at 20.0 ± 0.5 °C and a relative density of 0.983.

Description of key information

Relative density is 0.983 at 20 °C (OECD 109, pycnometer).

Key value for chemical safety assessment

Relative density at 20C:
0.983

Additional information