Pentyl D-glucoside

Short-term toxicity to aquatic invertebrates

Link to relevant study record(s)

Reference

Endpoint:

short-term toxicity to aquatic invertebrates

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Remarks:

Summary of available data used for the assessment of this endpoint for the target substance.

Adequacy of study:

key study

Justification for type of information:

Refer to the analogue approach justification provided in IUCLID section 13.

Reason / purpose for cross-reference:

read-across source

Reason / purpose for cross-reference:

read-across source

Duration:

48 h

Dose descriptor:

EC50

Effect conc.:

> 100 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mobility

Remarks on result:

other:

Remarks:

Source: RA-A, CAS 31387-97-0, Inst. Techn. FCBA, 2010, D. magna

Duration:

48 h

Dose descriptor:

EC50

Effect conc.:

> 51 mg/L

Nominal / measured:

nominal

Conc. based on:

act. ingr.

Basis for effect:

mobility

Remarks on result:

other:

Remarks:

Source: RA-A, CAS 31387-97-0, Inst. Techn. FCBA, 2010, D. magna

Duration:

48 h

Dose descriptor:

EC50

Effect conc.:

490 mg/L

Nominal / measured:

nominal

Conc. based on:

act. ingr.

Basis for effect:

mobility

Remarks on result:

other: 95% CL: 420 - 580 mg a.i./L

Remarks:

Source: RA-A, CAS 54549-24-5, Wetton, 1998, D. magna

Duration:

48 h

Dose descriptor:

NOEC

Effect conc.:

180 mg/L

Nominal / measured:

nominal

Conc. based on:

act. ingr.

Basis for effect:

mortality

Remarks on result:

other:

Remarks:

Source: RA-A, CAS 54549-24-5, Wetton, 1998, D. magna

Conclusions:

The key effect concentration retained for the assessment of the short-term toxicity of the target substance to aquatic invertebrates is an EC50 (48 h) of > 51 mg/L (act. ingr., OECD 202, D. magna, CAS 31387-97-0) based on the available read-across data.

Description of key information

EC50 (48 h) > 51 mg a.i./L (nominal, OECD 202, D. magna); read-across

EC50 (48 h) = 490 mg a.i./L (nominal, OECD 202, D. magna); read-across

Additional information

There is no study available, in which the short-term toxicity of the target substance D-Glucopyranose, oligomeric, pentyl glycosides (CAS 100231-63-8) to aquatic invertebrates was assessed. Therefore, read-across to the two structurally and chemically closely related source substances D-Glucopyranose, oligomeric, butyl glycoside (CAS 31387-97-0) and D-Glucopyranose, oligomers, hexyl glycosides (CAS 54549-24-5) was performed in accordance with Regulation (EC) No 1907/2006 Annex XI, 1.5 in order to meet the standard information requirements laid down in Annex VII of REACh Regulation (EC) No 1907/2006. Based on the high degree of physico-chemical similarity between the target and source substances, the selected source substances are considered suitable representatives for the assessment of the short-term toxicity of the target substance to aquatic invertebrates. A detailed read-across approach justification is provided in IUCLID section 13.

By means of the read-across approach, two key and two supporting studies are available for the assessment of the short-term toxicity of the target substance to aquatic invertebrates. All the available studies complied with GLP.

For the source substance D-Glucopyranose, oligomeric, butyl glycoside (CAS 31387-97-0), one key study is available, in which D. magna was exposed to nominal test item concentrations of 1, 10, and 100 mg/L of a 51% test item solution in a semi-static test design for 48 h (Inst. Techn. FCBA, 2010). The study was performed according to OECD 202. The actual test item concentration of the highest testing level was verified by TOC and resulted in 88.7 - 104.4% TOC recovery. After 48 h, no immobilization was observed, resulting in an EC50 (48 h) of > 100 mg/L (nominal), equivalent to > 51 mg a.i./L, the highest concentration tested.

For the source substance D-Glucopyranose, oligomers, hexyl glycosides (CAS 54549-24-5) two freshwater studies and one saltwater study are available. Neither study analytically verified the actual test item concentrations in the test vessels. The freshwater studies (key and supporting) were performed according to OECD guideline 202 using Daphnia magna. The key study (Wetton, 1998) resulted in an EC50 (48 h) of 490 mg a.i./L (nominal) and the supporting study (Wetton, 1997) resulted in an EC50 (48 h) of > 100 mg/L (test material, nominal).

The available supporting saltwater test (Larsen, 2003) was performed equivalently to ISO 14669 using Acartia tonsa as model organism and resulted in an LL50 (48 h) of 730 mg/L (nominal loading rate of water accommodated fraction).

Thus, the available results taken together indicate no hazard to aquatic invertebrates.

Based on the high degree of structural and physico-chemical similarity between the target and the selected source substances, the target substance is expected to exhibit a similar ecotoxicological profile as the source substances. Therefore, the target substance D-Glucopyranose, oligomeric, pentyl glycosides (CAS 100231-63-8) is not expected to cause toxic effects to aquatic invertebrates.