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EC number: -
CAS number: -
A study was performed to assess the irritancy potential of the test
material Reaction mass of N-butylphthalimide and N-sec-butylphthalimide
and N-propylphthalimide to the skin of the New Zealand white rabbit. The
method used followed that described in the OECD Guidelines for Testing
of chemicals(1981) No' 404 "Acute Dermal Irritation/Corrosion"
referenced as Method 84 in commission Directive 84/449/EEC. The results
may be used as a basis for classification and labelling according to the
Regulation 1272/2008/EC after reinterpretation of the raw data.
A single 4-hour, semi-occluded application of the test material to the
intact skin of three rabbits produced very slight to well-defined
erythema and very slight to slight oedema.
The mean value from gradings at 24, 48 and 72 hours after patch removal
calculated were the following:
- erythema/eschar: score 7/6=1.17 (2 out of 3 animals)
- oedema: 3/6=0.5 (2 out of 3 animals)
Incidents of desquamation and haemorrhage of the dermal capillaries were
also noted. On occasions the reactions extended beyond the treatment
sites. No corrosive effects were noted.
The test material is not corrosive and not irritant to skin according to
the regulation 1272/2008/EC.
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