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EC number: 257-473-3
CAS number: 51851-37-7
The key skin irritation study is an OECD Test Guideline 404 rabbit study
which concluded the substance was not irritating to the skin (Hüls,
1997c, reliability 1).
The key eye irritation study is an OECD Test Guideline 405 rabbit study
which concluded the substance was not irritating to the eye (Hüls,
1997d, reliability 1).
2-(Perfluorohexyl)ethyl]triethoxysilane has been tested for acute skin
irritation in a semi-occlusive study conducted according to OECD TG 404
and in compliance with GLP (Hüls, 1997c, reliability 1). Very slight
erythema was observed after 30-60 minutes, and 2, 48 and 72 hours, in
two of the three small white Russian rabbits exposed to the undiluted
test substance for four hours. One animal showed very slight edema 48
and 72 hours after the removal of the bandage. All signs of irritation
had reversed by 6 days after application. One animal showed no signs of
skin irritation during the entire observation period. It is concluded
that the test substance is not classifiable for irritation to the skin.
In an eye irritation study conducted according to OECD TG 405 and in
compliance with GLP, [2-(perfluorohexyl)ethyl]triethoxysilane was only
very slightly and transiently irritating to the eyes of small white
Russian rabbits and therefore was not classified as an eye irritant
(Hüls, 1997d, reliability 1).
Based on the available studies on skin and eye irritation,
[2-(perfluorohexyl)ethyl]triethoxysilane does not require classification
for skin or eye irritation according to Regulation (EC) 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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