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EC number: 257-473-3 | CAS number: 51851-37-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
The key skin irritation study is an OECD Test Guideline 404 rabbit study which concluded the substance was not irritating to the skin (Hüls, 1997c, reliability 1).
The key eye irritation study is an OECD Test Guideline 405 rabbit study which concluded the substance was not irritating to the eye (Hüls, 1997d, reliability 1).
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 10th March 1997 to 14th March 1997
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- yes (incl. QA statement)
- Species:
- rabbit
- Strain:
- other: small white Russian Mol:Russian / Chbb:HM
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Møllegaard Breeding/Research Centre Ltd., Tornbjergvej 40, Ejby DK-4623 LI. Skensved, Denmark
- Age at study initiation: no information
- Weight at study initiation: 2.3, 2.3 and 2.4 kg
- Housing: conventional, single animal per stainless steel cage.
- Diet: Ssniff K4 complete diet for rabbits ad libitum
- Water: tap water ad libitum
- Acclimation period: at least 14 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 +/- 3°C
- Humidity (%): 30-70%
- Air changes (per hr): 15
- Photoperiod (hrs dark / hrs light): 12/12 - Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 cm³
- Concentration (if solution): undiluted - Duration of treatment / exposure:
- Four hours
- Observation period:
- 30-60 minutes, 24, 48 and 72 hours, and 6 days after removal of the patch.
- Number of animals:
- Three
- Details on study design:
- TEST SITE
- Area of exposure: 6 cm²
- Type of wrap if used: gauze covered with a non-irritating bandage and then a semi-occlusive bandage.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): washed with warm water
- Time after start of exposure: four hours
SCORING SYSTEM: Draize - Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 6 days
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 6 days
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- <= 1
- Max. score:
- 4
- Remarks on result:
- other: very slight edema was observed at 48 and 72 hours after patch removal
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- [2-(perfluorohexyl)ethyl]triethoxysilane has been tested for acute skin irritation in a semi-occlusive study conducted according to OECD TG 404 and in compliance with GLP. Very slight erythema was observed after 30-60 minutes, and 2, 48 and 72 hours, in two of the three small white Russian rabbits exposed to the undiluted test substance for four hours. One animal showed very slight edema 48 and 72 hours after the removal of the bandage. All signs of irritation had reversed by 6 days after application. One animal showed no signs of skin irritation during the entire observation period. It is concluded that the test substance is not irritating to the skin.
- Endpoint:
- skin irritation: in vitro / ex vivo
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- an in vitro skin irritation study does not need to be conducted because adequate data from an in vivo skin irritation study are available
Referenceopen allclose all
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1997-03-10 to 1997-03-14
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
- Version / remarks:
- 1992
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Version / remarks:
- 1992
- GLP compliance:
- yes (incl. QA statement)
- Species:
- rabbit
- Strain:
- other: small white Russian
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Møllegaard Breeding/Research Centre, Ltd., Tombjergvej 40, Ejby, DK-4623 LI. Skensved, Denmark
- Age at study initiation: adult
- Weight at study initiation: 2.0-2.6 kg
- Housing: single animal per stainless steel cage
- Diet (e.g. ad libitum): Ssniff K 4, complete diet for rabbits, ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: at least 14 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20±3°C
- Humidity (%): 30-70% (deviations of short duration are caused by cleaning of the animal room)
- Air changes (per hr): 15 times
- Photoperiod (hrs dark / hrs light): artificial light 12/12
IN-LIFE DATES: From: 10th March 1997 to 14th March 1997 - Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- 0.1 cm³
- Duration of treatment / exposure:
- 24 hours
- Observation period (in vivo):
- Evaluation of the eyes was performed 1, 24, 48 and 72 hours after application of test substance
- Number of animals or in vitro replicates:
- 3 males
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): with warm physiological saline solution
- Time after start of exposure: 24 hours
TOOL USED TO ASSESS SCORE: fluorescein test - Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0.33
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- chemosis score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- chemosis score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- iris score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- iris score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- Within one hour of application, distinct hyperaemia of several blood vessels occurred in all animals. On one animal, the redness of the connective tissue was accompanied by a slight swelling, including the nictitating membrane. The cornea and iris showed no changes. Only one animal showed a slight redness of the connective tissue in the form of distinct hyperaemia of the blood vessels 24 hours after treatment. Further changes in the eye and conjunctiva were not observed. After 48 and 72 hours the eyes of all three animals were normal.
- Other effects:
- None reported.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In an eye irritation study conducted according to OECD 405 and to GLP, [2-(perfluorohexyl)ethyl]triethoxysilane was only very slightly and transiently irritating to the eyes of small white Russian rabbits and therefore was not classified as an eye irritant.
- Endpoint:
- eye irritation: in vitro / ex vivo
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- an in vitro eye irritation study does not need to be conducted because adequate data from an in vivo eye irritation study are available
Referenceopen allclose all
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
2-(Perfluorohexyl)ethyl]triethoxysilane has been tested for acute skin irritation in a semi-occlusive study conducted according to OECD TG 404 and in compliance with GLP (Hüls, 1997c, reliability 1). Very slight erythema was observed after 30-60 minutes, and 2, 48 and 72 hours, in two of the three small white Russian rabbits exposed to the undiluted test substance for four hours. One animal showed very slight edema 48 and 72 hours after the removal of the bandage. All signs of irritation had reversed by 6 days after application. One animal showed no signs of skin irritation during the entire observation period. It is concluded that the test substance is not classifiable for irritation to the skin.
In an eye irritation study conducted according to OECD TG 405 and in compliance with GLP, [2-(perfluorohexyl)ethyl]triethoxysilane was only very slightly and transiently irritating to the eyes of small white Russian rabbits and therefore was not classified as an eye irritant (Hüls, 1997d, reliability 1).
Justification for classification or non-classification
Based on the available studies on skin and eye irritation, [2-(perfluorohexyl)ethyl]triethoxysilane does not require classification for skin or eye irritation according to Regulation (EC) 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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