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EC number: 255-002-6
CAS number: 40615-36-9
Two study reports (rated as Klimisch
1) on aquatic organisms are available covering two trophic levels: a
primary producer (freshwater algae, represented by the model species Pseudokirchneriella
subcapitata) and a primary consumer (aquatic invertebrates,
represented by the model species Daphnia magna).
D. magna was exposed for 48
hours to 4,4'-Dimethoxytrityl chloride in a static short-term GLP
toxicity study (OECD 202) at a limit concentration of 4.3 mg/L
(measured, limit of water solubility, loading 100 mg/L nominal). No
effect on D. magna was observed. The test concentration was
determined analytically by HPLC-UV. Therefore, 4,4'-Dimethoxytrityl
chloride is not toxic to D. magna up to the limit of water
The freshwater algae P. subcapitata
was exposed to 4,4'-Dimethoxytrityl chloride for 72 hours in a GLP
toxicity study (OECD 201). In this study a 72 h ErC50(endpoint: growth
rate) of 1.629 mg/L (95 % C.L. 1.079 – 2.417 mg/L) and a 72 h NOErC
(endpoint: growth rate) of 0.537 mg/L were determined. The test
concentrations were determined analytically by HPLC-UV.
Taking into account that
4,4'-Dimethoxytrityl chloride is considered to be not readily
biodegradable based on ThCO2. (Flach 2018) and the lowest effect value
was determined to be > 1 mg/L (ErC50 = 1.629 mg/L), 4,4'-Dimethoxytrityl
chloride has to be classified as "Aquatic Chronic 2" (H411) following
the provisions laid down in the CLP Regulation (Regulation (EC) No
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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