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EC number: 255-002-6
CAS number: 40615-36-9
Results of the pre-experiment:
Table 2: Results of the
Solvent Control (DMSO)
In a reverse gene mutation assay in bacteria conducted according
to OECD 471, strains TA98, TA100, TA102, TA1535 and TA1537 of S.
typhimurium were exposed to 4,4'-Dimethoxytrityl chloride (99.73%
purity) dissolved in DMSO at concentrations of 31.6, 100, 316, 1000,
2500 and 5000 µg/plate in the presence and absence of mammalian
metabolic activation. The positive controls induced the appropriate
responses in the corresponding strains. There was no evidence of induced
mutant colonies over background in all tester strains and both
experiments (plate incorporation and pre-incubation). Based on the
results, 4,4'-Dimethoxytrityl chloride is considered to be non-mutagenic
in the bacterial reverse gene mutation assay.
This study is classified as acceptable. This study satisfies the
requirement for Test Guideline OPPTS 870.5100; OECD 471 for in vitro
mutagenicity (bacterial reverse gene mutation) data.
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