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Diss Factsheets

Ecotoxicological information

Short-term toxicity to aquatic invertebrates

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
Qualifier:
according to guideline
Guideline:
EU Method C.2 (Acute Toxicity for Daphnia)
GLP compliance:
yes (incl. QA statement)
Details on sampling:
This study encompassed 6 treatment groups (5 dose rates of the test item and a control) each containing 20 individuals. The mobility of the daphnids was determined in a static 48-hour test by visual observation after 24 and 48 hours.
Vehicle:
no
Details on test solutions:
At the start of the test 86 % of the nominal test concentrations were found (average of all test concentrations). After 48 hours test duration, 86 % of the nominal value was determined (average of all test concentrations). During the test the daphnids were exposed to a mean of 86 % of nominal.
Test organisms (species):
Daphnia magna
Details on test organisms:
Female Daphnia magna, clone 5; 1.5 to 20 hours old
Source: The daphnids introduced in the test were taken from ibacon's in-house laboratory culture.
Test type:
static
Test temperature:
19.2 to 19.8 °C
pH:
7.9 to 8.3
Dissolved oxygen:
8.7 to 8.9 mg/L
Nominal and measured concentrations:
100, 50, 25, 12.5 and 6.25 mg test item/L and a control.
Details on test conditions:
photoperiod: 16 h light - 8 h dark; light intensity: 390 to 590 lux
Reference substance (positive control):
no
Key result
Duration:
24 h
Dose descriptor:
EC50
Effect conc.:
> 100 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mobility
Key result
Duration:
48 h
Dose descriptor:
EC50
Effect conc.:
> 100 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mobility
Key result
Duration:
24 h
Dose descriptor:
EC10
Effect conc.:
> 100 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mobility
Key result
Duration:
48 h
Dose descriptor:
EC10
Effect conc.:
> 100 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mobility
Key result
Duration:
24 h
Dose descriptor:
NOEC
Effect conc.:
>= 100 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mobility
Key result
Duration:
48 h
Dose descriptor:
NOEC
Effect conc.:
>= 100 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mobility
Key result
Duration:
24 h
Dose descriptor:
LOEC
Effect conc.:
> 100 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mobility
Key result
Duration:
48 h
Dose descriptor:
LOEC
Effect conc.:
> 100 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mobility
Details on results:
The initial concentrations and the maintenance of the exposure concentrations during the test were verified in the analytical part. All reported results refer to nominal values since the concentrations of the test item were within ± 20% of the nominal concentrations during the test.
nominal concentration [mg test item/L] % of immobilised daphnides after 24 h % of immobilised daphnides after 48 h
 0 (control)  0  0
 6.25  0  0
 12.5  0  0
 25  0  0
 50  0  0
 100  0  0
Validity criteria fulfilled:
yes
Conclusions:
The toxic effect of the test item Potassium perchlorate to Daphnia magna was assessed in a static concentration-response test. The 48-hour NOEC was determined to be ≥100 mg test item/L. The 48-hour LOEC was determined to be >100 mg test item/L and the 48-hour EC50 value was determined to be >100 mg test item/L.

Description of key information

The toxic effect of the test item Potassium perchlorate to Daphnia magna was assessed in a static concentration-response test. The 48-hour NOEC was determined to be ≥100 mg test item/L. The 48-hour LOEC was determined to be >100 mg test item/L and the 48-hour EC50 value was determined to be >100 mg test item/L.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
100 mg/L

Additional information