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EC number: 272-729-4 | CAS number: 68910-05-4 A complex residuum from the fractionation of the reaction products of 2-aminoethanol with ammonia to remove piperazine. It may contain such compounds as 2-[(2-aminoethyl)amino]ethanol, (aminoethyl)piperazine, (hydroxyethyl)piperazine.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Reliable studies are available for CAS 68910-05-4 concerning skin and eye irritation.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Well documented study report, acceptable for assessment
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Gaukler, Germany
- Weight at study initiation: 2.78, 2.63, 2.88, 2.80, 2.73, 2.56 kg
- Housing: individual, stainless steel cages without beddings
- Diet Ovator Solikanin, Muskator-Werke, Düsseldorf, Germany; 130 g /day
- Water Tap water 250 ml/day
- Acclimation period: 8 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-24
- Humidity (%): 30-70
- Photoperiod (hrs dark / hrs light): 12/12 - Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 ml
- Concentration (if solution): undiluted - Duration of treatment / exposure:
- 4 hours
- Observation period:
- 8 days
- Number of animals:
- 6 (2 males, 4 females)
- Details on study design:
- TEST SITE
- Area of exposure: 2.5 x 2.5 cm
- Type of wrap if used:
REMOVAL OF TEST SUBSTANCE
- Washing (if done): Lutrol and Lutrol 50% diluted in water
- Time after start of exposure: 4 hour
SCORING SYSTEM:
according to OECD Draize scores
Readings: 30-60 min, 24 h, 48 h, 72 h, 8 days after substance removal - Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- 1-6
- Time point:
- 24/48/72 h
- Score:
- 2.27
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 8 days
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- 1-6
- Time point:
- 24/48/72 h
- Score:
- 1.06
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 8 days
- Interpretation of results:
- corrosive
Reference
Readings |
Animal |
Exposure period: 4 h |
||
Erythema |
Edema |
Additional findings |
||
4 h |
1 |
2 |
1 |
R:U/OE:U |
2 |
2 |
1 |
R:U/OE:U |
|
3 |
2 |
1 |
R:U/OE:U/HE |
|
4 |
2 |
1 |
R:U/OE:U |
|
5 |
2 |
2 |
R:U/OE:U/HE |
|
6 |
1 |
0 |
R:U |
|
24 h |
1 |
2 |
1 |
R:U/OE:U |
2 |
2 |
1 |
R:U/OE:U |
|
3 |
4 |
2 |
N/OE:U |
|
4 |
2 |
1 |
R:U/OE:U |
|
5 |
2 |
1 |
R:U/OE:U/HE |
|
6 |
1 |
0 |
R:U |
|
48 h |
1 |
2 |
1 |
HE |
2 |
3 |
1 |
R:U/OE:U/HE |
|
3 |
4 |
2 |
N |
|
4 |
2 |
1 |
|
|
5 |
2 |
1 |
R:U/OE:U/HE |
|
6 |
1 |
0 |
R:U |
|
72 h |
1 |
2 |
1 |
HE |
2 |
3 |
2 |
HE |
|
3 |
4 |
2 |
N |
|
4 |
2 |
1 |
|
|
5 |
2 |
1 |
R:U/OE:U/HE |
|
6 |
1 |
0 |
R:U |
|
8 d |
1 |
1 |
0 |
S/+ |
2 |
1 |
0 |
S/+ |
|
3 |
4 |
2 |
N:TI/+ |
|
4 |
1 |
0 |
S/+ |
|
5 |
4 |
1 |
N:OB/+ |
|
6 |
1 |
0 |
S/+ |
|
Mean 24, 48, 72 h |
1 |
2 |
1 |
|
2 |
2.66 |
1.33 |
|
|
3 |
4 |
2 |
|
|
4 |
2 |
1 |
|
|
5 |
2 |
1 |
|
|
6 |
1 |
0 |
|
|
Mean 24, 48, 72 h |
1-6 |
2.27 |
1.055 |
|
Symbols:
HE haemorrhagia
N necrosis
N:TI necrosis (deep)
N:OB necrosis (superficial)
OE:U oedema exceeding beyond area of exposure
S desquamation
+ pathologically confirmed
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Well documented study report, acceptable for assessment
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Gaukler, Germany
- Weight at study initiation: 2.24, 2.77, 3.28 kg
- Housing: individual, stainless steel cages without beddings
- Diet Ovator Solikanin, Muskator-Werke, Düsseldorf, Germany; 130 g /day
- Water Tap water 250 ml/day
- Acclimation period: 8 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-24
- Humidity (%): 30-70
- Photoperiod (hrs dark / hrs light): 12/12 - Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 ml
- Concentration (if solution): unchanged - Duration of treatment / exposure:
- not applicable, because test substance remained in the eye and was not washed out
- Observation period (in vivo):
- 72 hours
- Number of animals or in vitro replicates:
- 3
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): none
SCORING SYSTEM: according to OECD Draize system - Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Remarks:
- 1-3
- Time point:
- 24/48/72 h
- Score:
- 2.55
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritation parameter:
- other: cornea area
- Basis:
- mean
- Remarks:
- 1-3
- Time point:
- 24/48/72 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritation parameter:
- iris score
- Basis:
- mean
- Remarks:
- 1-3
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 2
- Reversibility:
- not reversible
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Remarks:
- 1-6
- Time point:
- 24/48/72 h
- Score:
- 3
- Max. score:
- 3
- Reversibility:
- not reversible
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Remarks:
- 1-3
- Time point:
- 24/48/72 h
- Score:
- 2.89
- Max. score:
- 3
- Reversibility:
- not reversible
Reference
Readings |
Animal |
Cornea |
Iris |
Conjunctiva |
Additional findings |
|||
op |
ar |
red |
ch |
di |
||||
1 h |
1 |
2 |
4 |
2 |
3 |
2 |
3 |
PC |
2 |
2 |
4 |
2 |
3 |
3 |
2 |
PC |
|
3 |
1 |
4 |
1 |
3 |
2 |
3 |
PC |
|
24 h |
1 |
2 |
4 |
2 |
3 |
3 |
3 |
E, PC |
2 |
2 |
4 |
2 |
3 |
3 |
2 |
E, PC |
|
3 |
2 |
4 |
2 |
3 |
2 |
2 |
E, Pv, Na |
|
48 h |
1 |
2 |
4 |
2 |
3 |
3 |
3 |
SI/Na |
2 |
2 |
4 |
2 |
3 |
3 |
2 |
E, PC, Na |
|
3 |
2 |
4 |
2 |
3 |
3 |
2 |
E, PC, Na |
|
72 h |
1 |
4 |
4 |
2 |
3 |
3 |
3 |
S1/Na |
2 |
4 |
4 |
2 |
3 |
3 |
3 |
E, Na |
|
3 |
3 |
4 |
2 |
3 |
3 |
3 |
E, Pv, Na |
|
Mean 24 -72 h |
1 |
2.66 |
4 |
2 |
3 |
3 |
3 |
|
2 |
2.66 |
4 |
2 |
3 |
3 |
2.33 |
|
|
3 |
2.33 |
4 |
2 |
3 |
2.66 |
2.33 |
|
|
Mean 24-72 h |
1-3 |
2.55 |
4 |
2 |
3 |
2.89 |
2.55 |
|
Symbols:
S1: reading not possible due to pus formation
E: pus formation
PC: Pupil contracted
Na: scars at the eyelids
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
Effects on skin irritation/corrosion: corrosive
Effects on eye irritation: corrosive
Justification for classification or non-classification
According to EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008, the classification criteria for skin corrosion (cat. 1B) (H314: Causes severe skin burns and eye damage) are met.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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