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EC number: 272-729-4
CAS number: 68910-05-4
A complex residuum from the fractionation of the reaction products of 2-aminoethanol with ammonia to remove piperazine. It may contain such compounds as 2-[(2-aminoethyl)amino]ethanol, (aminoethyl)piperazine, (hydroxyethyl)piperazine.
Aminoethylethanolamine (AEEA) exhibited clear signs of irritation of the ear skin at a concentration of 30%. It had been reported to be skin-sensitizing in a guinea pig maximization test after intradermal induction with 5%, epidermal induction with 50% in distilled water, and challenge with 25% in distilled water, showing a response in 40% of the animals (Leung and Auletta, 1997). According to the categorization proposed in the ECETOC Technical Report No. 87, this makes it a weak sensitizer. On the other hand, an unpublished report (CTL, 2001) about an LLNA with 2.5%, 5%, 10% and 20% AEEA in acetone/olive oil (4:1) presents stimulation indices (SIs) of 2.2, 2.8, 6.3 and 14.7, resulting in an EC3 value of 5.3%, i.e. ‘‘moderate”. This is a clearly lower EC3 than that observed in the present study (13–15% depending on endpoint evaluated and method of calculation), but the AEEA study described in the unpublished report, which investigated a number of ethyleneamines, showed the lowest vehicle control value of [3H]-thymidine incorporation (range 197–386 dpm/lymph node). If the SIs had been calculated using the upper end of the vehicle control values, an EC3 of about 10% would have resulted. In conclusion, AEEA is a weak skin sensitizer and skin irritant.
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