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EC number: 215-222-5
CAS number: 1314-13-2
Due to homeostatic control mechanisms, bioaccumulation is not relevant
to essential elements in general and to zinc in particular.
In experimental work, high BCF factors are observed at the lowest zinc
exposure levels, due to the fact that organisms will concentrate zinc to
satisfy internal physiological needs for the essential element. For the
same reason of homeostasis, the BCF will strongly decrease when exposure
concentrations increase. This results in a general negative relationship
between BCF and exposure (McGeer et al 2003).
On bioaccumulation, the EU risk assessment report (ECB 2008) concluded
that “secondary poisoning is considered to be not relevant in the
effect assessment of zinc. Major decision points for this conclusion are
the following. The accumulation of zinc, an essential element, is
regulated in animals of several taxonomic groups, for example in
molluscs, crustaceans, fish and mammals. In mammals, one of the two
target species for secondary poisoning, both the absorption of zinc from
the diet and the excretion of zinc, are regulated. This allows mammals,
within certain limits, to maintain their total body zinc level (whole
body homeostasis) and to maintain physiologically required levels of
zinc in their various tissues, both at low and high dietary zinc
intakes. The results of field studies, in which relatively small
differences were found in the zinc levels of small mammals from control
and polluted sites, are in accordance with the homeostatic mechanism.
These data indicate that the bioaccumulation potential of zinc in both
herbivorous and carnivorous mammals will be low."
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