N,N-bis[3-(dimethylamino)propyl]-N',N'-dimethylpropane-1,3-diamine

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: No GLP

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1987

Report date:

1987

Materials and methods

Test guideline

Test guideline 1

Qualifier:

no guideline followed

Test guideline 2

Qualifier:

equivalent or similar to guideline

Guideline:

EU Method B.1 (Acute Toxicity (Oral))

Deviations:

not specified

Principles of method if other than guideline:

Non GLP toxicity study.

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

N,N-bis[3-(dimethylamino)propyl]-N',N'-dimethylpropane-1,3-diamine

EC Number:

251-459-0

EC Name:

N,N-bis[3-(dimethylamino)propyl]-N',N'-dimethylpropane-1,3-diamine

Cas Number:

33329-35-0

Molecular formula:

C15H36N4

IUPAC Name:

(3-{bis[3-(dimethylamino)propyl]amino}propyl)dimethylamine

Test material form:

gas under pressure: refrigerated liquefied gas

Test animals

Species:

other: Rat and Mouse

Sex:

male/female

Administration / exposure

Route of administration:

oral: drinking water

Vehicle:

water

Control animals:

not specified

Results and discussion

Effect levels

Sex:

male

Dose descriptor:

LD50

Effect level:

ca. 2.81 mL/kg bw

Based on:

test mat.

95% CL:

> 2.34 - <= 3.26

Applicant's summary and conclusion

Interpretation of results:

sligthly toxic

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

Rat - Acute Oral LD50 = 2385 mg/kg
Mouse - Acute Oral LD50 = 2597 mg/kg