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EC number: 251-459-0
CAS number: 33329-35-0
The substance is severely irritating and corrosive to the skin, eyes and respiratory tract.No thresholds are definable for the corrosive/irritant effects.
Both nominal and actual exposure concentrations were determined for the
LC50 study. Nominal concentrations were determined by weighing the
amount of test material placed in the generator reservoir prior to
exposure and then again following exposure. The difference in weight
was divided by the total air passed through the chamber during the
exposure period. Actual exposure concentrations were determined by
standard gravimetric techniques.
The results indicated that nominal concentrations were higher than
actual concentrations, e.g. 11.3 mg/L versus 2.8 mg/L for the highest
concentration. Since B.P.>200°C, and vapour pressure=0.172
lb/inch3) this is a liquid material with low volatility, the actual
measured concentrations seem more appropriate for evaluation of toxicity.
In conclusion, at actual exposure concentrations of 1.1-2.8 mg/L
(nominal concentrations of 3.6-11.3 mg/L) for four hours produced signs
of toxicity and deaths in rats. The combined male and female 4-hour LC50
values for actual measured concentrations and nominal concentrations
were estimated to be 1.9 mg/L and 6.9 mg/L, respectively.
Male Rabbit LD50 1120 mg/kg (unabraded skin)
Female Rabbit LD50 1171 mg/kg (unabraded skin)
Male Rabbit LD50 1400 mg/kg (abraded skin)
Female Rabbit LD50 976 mg/kg (abraded skin)
The substance is severely irritating and corrosive to the skin, eyes and
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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