Fatty acids, C8-10, C12-18-alkyl esters

Hydrolysis

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

hydrolysis

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

the study does not need to be conducted because the substance is readily biodegradable

Reference 2

Endpoint:

hydrolysis

Type of information:

(Q)SAR

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

results derived from a (Q)SAR model, with limited documentation / justification, but validity of model and reliability of prediction considered adequate based on a generally acknowledged source

Justification for type of information:

More information about the valididty of the QSAR calculation is given under "Any other information on materials and methods"

Principles of method if other than guideline:

Calculation based on HYDROWIN v2.00, Estimation Programs Interface Suite™ for Microsoft® Windows v 4.10. US EPA, United States Environmental Protection Agency, Washington, DC, USA.

GLP compliance:

no

Estimation method (if used):

- Total Kb for pH > 8: 1.077E-002 L/mol sec
- Temperature for which rate constant was calculated: 25 °C
- Computer programme: HYDROWIN v2.00

pH:

7

Temp.:

25 °C

DT50:

20.398 yr

pH:

8

Temp.:

25 °C

DT50:

2.04 yr

Details on results:

For detailed description on the model and its applicability, see "Any other information on materials and methods incl. tables".

Result refers to the uncharged molecule.

Reference 3

Endpoint:

hydrolysis

Type of information:

(Q)SAR

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

results derived from a (Q)SAR model, with limited documentation / justification, but validity of model and reliability of prediction considered adequate based on a generally acknowledged source

Justification for type of information:

More information about the valididty of the QSAR calculation is given under "Any other information on materials and methods"

Principles of method if other than guideline:

Calculation based on HYDROWIN v2.00, Estimation Programs Interface Suite™ for Microsoft® Windows v 4.10. US EPA, United States Environmental Protection Agency, Washington, DC, USA.

GLP compliance:

no

Estimation method (if used):

- Total Kb for pH > 8: 1.077E-002 L/mol sec
- Temperature for which rate constant was calculated: 25 °C
- Computer programme: HYDROWIN v2.00

pH:

7

Temp.:

25 °C

DT50:

20.398 yr

pH:

8

Temp.:

25 °C

DT50:

2.04 yr

Details on results:

For detailed description on the model and its applicability, see "Any other information on materials and methods incl. tables".

Result refers to the uncharged molecule.

Reference 4

Endpoint:

hydrolysis

Type of information:

(Q)SAR

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

results derived from a (Q)SAR model, with limited documentation / justification, but validity of model and reliability of prediction considered adequate based on a generally acknowledged source

Justification for type of information:

More information about the valididty of the QSAR calculation is given under "Any other information on materials and methods"

Principles of method if other than guideline:

Calculation based on HYDROWIN v2.00, Estimation Programs Interface Suite™ for Microsoft® Windows v 4.10. US EPA, United States Environmental Protection Agency, Washington, DC, USA.

GLP compliance:

no

Estimation method (if used):

- Total Kb for pH > 8: 2.369E-002 L/mol sec
- Temperature for which rate constant was calculated: 25 °C
- Computer programme: HYDROWIN v2.00

pH:

7

Temp.:

25 °C

DT50:

9.272 yr

pH:

8

Temp.:

25 °C

DT50:

338.674 yr

Details on results:

For detailed description on the model and its applicability, see "Any other information on materials and methods incl. tables".

Result refers to the uncharged molecule.

Reference 5

Endpoint:

hydrolysis

Type of information:

(Q)SAR

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

results derived from a (Q)SAR model, with limited documentation / justification, but validity of model and reliability of prediction considered adequate based on a generally acknowledged source

Justification for type of information:

More information about the valididty of the QSAR calculation is given under "Any other information on materials and methods"

Principles of method if other than guideline:

Calculation based on HYDROWIN v2.00, Estimation Programs Interface Suite™ for Microsoft® Windows v 4.10. US EPA, United States Environmental Protection Agency, Washington, DC, USA.

GLP compliance:

no

Estimation method (if used):

- Total Kb for pH > 8: 2.369E-002 L/mol sec
- Temperature for which rate constant was calculated: 25 °C
- Computer programme: HYDROWIN v2.00

pH:

7

Temp.:

25 °C

DT50:

9.272 yr

pH:

8

Temp.:

25 °C

DT50:

338.674 yr

Details on results:

For detailed description on the model and its applicability, see "Any other information on materials and methods incl. tables".

Result refers to the uncharged molecule.

Description of key information

Hydrolysis is not relevant due to ready biodegradation.

Additional information

No experimental studies investigating the abiotic hydrolysis fatty acids, C8-10, C12-18-alky esters (CAS 95912-86-0) are available. However, in accordance with Annex VIII, column 2, 9.2.2.1. of Regulation (EC) No 1907/2006, testing is not required since the substance is readily biodegradable. In addition, a supporting QSAR calculation (HYDROWIN v2.00) indicates, that hydrolysis is a negligible pathway for the environmental fate of the test substance in the environment (DT50 > 1 yr (pH 7); Müller, 2011).