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EC number: 205-250-6
CAS number: 136-52-7
Table 1: Pharmacokinetic parameter
Pharmacokinetic parameters of cobalt dichloride hexahydrate, tricobalt tetraoxide or cobalt stearat in rats (Non-compartmental analysis)
Dose level [mg/kg]
Cobalt dichloride hexa-hydrate
dose correction to the Cobalt content was performed.
- : not
- clinical signs: no signs of local
intolerance reactions were noted at the injection sites of the rats
treated once intravenously with 0.1 mg cobalt dichloride hexahydrate/kg
bw. None of the rats treated once intravenously with 0.1 mg cobalt
dichloride hexahydrate/kg bw showed any changes in behaviour or external
None of the rats treated once orally with 10
mg cobalt dichloride hexahydrate/kg bw, 300 mg tricobalt tetraoxide/kg
bw or 5 mg cobalt stearate/kg bw showed any changes in behaviour or
The faeces of the animals were normally
None of the rats died prematurely.
- body weight: individual body weights
ranged from 265.0 to 315.2 g for the male animals and from 149.5 to
183.2 g for the female animals on test day 1 and were within the
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