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Diss Factsheets
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EC number: 205-250-6 | CAS number: 136-52-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
- Plants: 83 NOEC/EC10 values for monocotyledon and dicotyledon species including agricultural species belonging to 7 different species and 4 different families (Brassica napus and Raphanus sativus – family of the Brassicaceae; Lycopersicon esculentum – family of the Solanaceae; Trifolium pratense and Medicago sativa – family of the Fabaceae; Hordeum vulgare and Elymus lanceolatus– family of the Poaceae).
- Invertebrates: 30 NOEC/EC10 values; hard and soft bodied organisms with different exposure routes and feeding strategies belonging to 4 different species and 3 different families (i.e. the Eisenia andrei and Eisenia fetida belonging to the family of the Lumbricidae; Enchytraeus albidus belonging to the family of the Enchytraeidae and Folsomia candida belonging to the family of the Isotomidae).
- Microbial processes: 28 NOEC/EC10 values; 3 different endpoints representing the C- and N-cycle are available (i.e. maize induced mineralisation, glucose induced respiration, and nitrification).
A robust data set is available for evaluating the toxicity of cobalt to terrestrial organisms and processes. All data met the requirements for classification as Klimisch 1 or 2 (Klimisch et al 1997). In total, 141 individual NOEC/EC10 values were compiled from the database, resulting in 14 different ‘species/process mean’ NOEC/EC10 values.
The terrestrial Co-database covers ecologically relevant endpoints. The selected endpoints are all relevant for potential effects at the population level: shoot and root yield based on weigh or length for the terrestrial plants; reproduction for the invertebrates; N- and C-transformation processes for microbial biomass.
Data are either from tests focusing on sensitive life stages (e.g. root elongation) or from “chronic exposure” (e.g. growth, reproduction). What comprises “chronic exposure” depends on the exposure duration and is also a function of the life-cycle of the test organisms. The duration should therefore be related to the typical life-cycle and to the recommended exposure duration from standard ecotoxicity protocols. For plants, exposure times of 14 to 21 days following emergence are used according to the ISO 11269-2 guideline (1995) for the shoot and root yield tests. An exposure time of 4 days was used for the root elongation tests with Hordeum vulgare according to the ISO 11269-1 (1993) guideline. The exposure time for the invertebrate tests varied between 28 days for Eisenia andrei (ISO 11268 (1996)) and Folsomia candida (ISO 11267 (1999)) and 42 days for Enchytraeus albidus (OECD 220 (2004)). Exposure times for microbial tests ranged between 1 day (Substrate induced respiration) and 28 days (maize residue mineralisation).
The reliable EC10/NOEC data were extracted from tests performed in natural and artificial soils, covering a wide range of the soil characteristics in Europe (pH value, organic matter, clay and effective cation exchange capacity (eCEC). It can be concluded that the soils covered by the toxicity data for each trophic level (plants, invertebrates and micro-organisms) properly reflect the variability in physico-chemical conditions encountered in European soils.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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