Trimethoxyvinylsilane

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1984

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

comparable to guideline study with acceptable restrictions

Remarks:

The GLP status of the study is uncertain.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1984

Report date:

1984

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

GLP compliance:

not specified

Remarks:

Although a statement regarding GLP was not available with the study report, it is known that this laboratory conducted studies in compliance with GLP at this time.

Test type:

other: LD50

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Trimethoxyvinylsilane

EC Number:

220-449-8

EC Name:

Trimethoxyvinylsilane

Cas Number:

2768-02-7

Molecular formula:

C5H12O3Si

IUPAC Name:

ethenyltrimethoxysilane

Test material form:

liquid

Test animals

Species:

rat

Strain:

Wistar

Remarks:

Hilltop Wistar albino

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS

- Weight at study initiation: 200- 300g

Administration / exposure

Route of administration:

other: intubation

Vehicle:

unchanged (no vehicle)

Details on oral exposure:

MAXIMUM DOSE VOLUME APPLIED: not reported

Doses:

16.0, 8.0, 4.0, 2.0 and 1.0 ml/kg bw in males; 16.0, 8.0, 4.0 and 2.0 ml/kg bw in females

No. of animals per sex per dose:

45

Control animals:

not specified

Details on study design:

- Duration of observation period following administration: 14 days

- Frequency of observations and weighing: Body weights were recorded on days 0, (before dosing), 7 and 14 (prior to termination).

- Necropsy of survivors performed: yes.

- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other: At necropsy, each animal was subjected to gross pathologic evaluation.

Statistics:

LD50 with 95% confidence limits; males 7.34 (4.61 to 11.7) ml/kg; females 7.46 (5.16 to 10.8) ml/kg. LD50 slopes; males 3.67, females 4.22.

Results and discussion

Effect levels

Key result

Sex:

male/female

Dose descriptor:

LD50

Effect level:

ca. 7.34 - ca. 7.46 mL/kg bw

Based on:

test mat.

Remarks on result:

other: Equivalent to 6899 and 7012 mg/kg bw based on relative density of 0.94 g/cm3

Mortality:

Deaths occurred at 2.5 hours to 4 days.

Clinical signs:

other: Sluggishness, red to brown discharge (around nose, eyes and anus), lacrimation, piloerection, unkempt appearance, prostation, emaciation and unsteady gait were amongst the signs of toxicity observed. Survivors recovered at one to 5 days. With the exceptio

Gross pathology:

At necropsy, there were several instances of dark red kidney section among victims.

Any other information on results incl. tables

 Table 1: Number of animals dead and time range within which mortality occurred.

 

Dose (ml/kg)	Mortality (# dead/total)			Time range of deaths (days)
	Male	Female	Combined
16	5/5	5/5	10/10	0 and 1
8	3/5	3/5	6/10	1,2,3,4
4	0/5	0/5	0/10
2	1/5	0/5	1/10	3
1	0/5	0/5	0/10

 

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

The acute oral toxicity study, conducted according to OECD Test Guideline 401 with uncertain GLP status, the concluded LD50 values for male and female rats were 7.34 ml/kg and 7.46 ml/kg (equivalent to 6899 and 7012 mg/kg bw based on relative density of 0.94 g/cm3), respectively.