Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 220-449-8 | CAS number: 2768-02-7
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- other: worker exposure
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Summary data was available for review
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Skin Sensitisation Properties of Trimethoxyvinylsilane (CAS No. 2768-02-7) – Experience in Humans
- Author:
- Momentive
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- other: review of worker medical data
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- no
Test material
- Reference substance name:
- Trimethoxyvinylsilane
- EC Number:
- 220-449-8
- EC Name:
- Trimethoxyvinylsilane
- Cas Number:
- 2768-02-7
- Molecular formula:
- C5H12O3Si
- IUPAC Name:
- ethenyltrimethoxysilane
Constituent 1
Method
- Type of population:
- occupational
- Ethical approval:
- not specified
Results and discussion
- Results of examinations:
- Trimethoxy(vinyl)silane is manufactured in a plants running a 5 shift process on approximately 300 days a year.
Over the course of 18 years 18 people have been in contact with the manufacturing process continuously without any indication of sensitization. An additional 24 people had been in contact with the substance during a 2 shift operational function. There is no evidence of any potential sensitization in the health files of all those individuals over the full manufacturing time.
Applicant's summary and conclusion
- Conclusions:
- There is no evidence of any potential sensitization in the health files of all those individuals exposed to trimethoxy(vinyl)silane over many years of manufacturing.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
