Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 224-052-0 | CAS number: 4180-23-8
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 971
- Report date:
- 1971
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method B.3 (Acute Toxicity (Dermal))
- GLP compliance:
- not specified
- Test type:
- fixed dose procedure
- Limit test:
- no
Test material
- Reference substance name:
- (E)-anethole
- EC Number:
- 224-052-0
- EC Name:
- (E)-anethole
- Cas Number:
- 4180-23-8
- Molecular formula:
- C10H12O
- IUPAC Name:
- 1-methoxy-4-prop-1-en-1-ylbenzene
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 2.5-3.0 kg
- Housing: Individually housed
- Diet: commercial diet
- Water: ad libitum
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: 240 cm2
- % coverage: 10%
- Type of wrap if used: Rubber sleeve and Webril padding
REMOVAL OF TEST SUBSTANCE
- Time after start of exposure: 24h
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 4900 mg/kg
- Constant volume or concentration used: yes/no - Duration of exposure:
- 24h
- Doses:
- 4900 mg/kg bw
- No. of animals per sex per dose:
- 6 (male/female)
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: daily
- Necropsy of survivors performed: yes - Statistics:
- no data
Results and discussion
Effect levels
- Dose descriptor:
- LD50
- Effect level:
- > 4 900 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No deaths.
- Clinical signs:
- other: Edema (3 of 6 rabbits), Erythema (6/6), Dicoloration (-), Scaling (6/6), Necrosis (-) and Eschar formation (2/6)
- Gross pathology:
- There was no tissue damage observed in rabbits killed at the termination of the study.
- Other findings:
- No data
Any other information on results incl. tables
The acute dermal LD50 value appear to be greater than 4900 mg/kg bw. No toxic signs were observed in rabbits receiving test material during the 14 -day observation period.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Anethole is not classified according to Regulation (EC) No 1272/2008
- Executive summary:
Anethole was screened for acute dermal toxicity in rabbits. Test material (4900 mg/kg bw) produced no deaths, it is assumed that the acute dermal LD50 value is above 4900 mg/kg bw in rabbits.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
