Registration Dossier
Registration Dossier
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EC number: 224-052-0 | CAS number: 4180-23-8
Toxicological information
Toxicological Summary
Currently viewing:
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 10.57 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 25
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 264.25 mg/m³
- Explanation for the modification of the dose descriptor starting point:
- Oral exposure is highly unexpected. Inhalation exposure is predictible due to the products in which the substance is contained.
- AF for dose response relationship:
- 1
- Justification:
- When the starting point for the DNEL calculation is a NOAEL, the default assessment factor, as a standard procedure, is 1.
- AF for differences in duration of exposure:
- 2
- Justification:
- The default assessment factor for subchronic to chronic is 2
- AF for interspecies differences (allometric scaling):
- 2.5
- Justification:
- Default AF for interspecies
- AF for intraspecies differences:
- 5
- Justification:
- Default AF for workers
- AF for the quality of the whole database:
- 1
- Justification:
- Data used in the DNEL derivation are reliable
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 7.5 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 40
- Modified dose descriptor starting point:
- other: NOAEC
- Value:
- 300 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
- Oral exposure is highly unexpected. Inhalation exposure is predictible due to the products in which the substance is contained.
- AF for dose response relationship:
- 1
- Justification:
- When the starting point for the DNEL calculation is a NOAEL, the default assessment factor, as a standard procedure, is 1.
- AF for differences in duration of exposure:
- 2
- Justification:
- the default assessment factor for subchronic to chronic is 2
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- Default AF for interspecies
- AF for intraspecies differences:
- 5
- Justification:
- Default AF for workers
- AF for the quality of the whole database:
- 1
- Justification:
- Data used in the DNEL derivation are reliable
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - workers
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 5.28 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 50
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 264.47 mg/m³
- Explanation for the modification of the dose descriptor starting point:
- Oral exposure is highly unexpected. Inhalation exposure is predictible due to the products in which the substance is contained.
- AF for dose response relationship:
- 1
- Justification:
- When the starting point for the DNEL calculation is a NOAEL, the default assessment factor, as a standard procedure, is 1.
- AF for differences in duration of exposure:
- 2
- Justification:
- The default assessment factor for subchronic to chronic is 2
- AF for interspecies differences (allometric scaling):
- 2.5
- Justification:
- Default AF for interspecies
- AF for intraspecies differences:
- 10
- Justification:
- Default AF for workers
- AF for the quality of the whole database:
- 1
- Justification:
- Data used in the DNEL derivation are reliable
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 3.75 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 80
- Modified dose descriptor starting point:
- other: NOAEC
- Value:
- 300 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
- Oral exposure is highly unexpected. Inhalation exposure is predictible due to the products in which the substance is contained.
- AF for dose response relationship:
- 1
- Justification:
- When the starting point for the DNEL calculation is a NOAEL, the default assessment factor, as a standard procedure, is 1.
- AF for differences in duration of exposure:
- 2
- Justification:
- The default assessment factor for subchronic to chronic is 2
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- Default AF for interspecies
- AF for intraspecies differences:
- 10
- Justification:
- Default AF for workers
- AF for the quality of the whole database:
- 1
- Justification:
- Data used in the DNEL derivation are reliable
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - General Population
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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