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EC number: 224-052-0 | CAS number: 4180-23-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Long-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 211 (Daphnia magna Reproduction Test)
- GLP compliance:
- yes
Test material
- Reference substance name:
- (E)-anethole
- EC Number:
- 224-052-0
- EC Name:
- (E)-anethole
- Cas Number:
- 4180-23-8
- Molecular formula:
- C10H12O
- IUPAC Name:
- 1-methoxy-4-prop-1-en-1-ylbenzene
Constituent 1
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- Species: Daphnia magna
Variety: STRAUS
Strain: Berlin
Sex: female
Age: between 0 and 24 hours
Study design
- Water media type:
- other: Deionised water with an enrichment of certain minerals was used in the test
- Total exposure duration:
- 21 d
- Remarks on exposure duration:
- Loading: 80 mL/animal, animals were kept individually Replicates: 10 replicates/treatment Blank Control : dilution water Lighting: 1000Lux Aeration: none Feeding: 0.15-0.20 mg org. carbon/animal/day, the amount of C is based on photometric measurement
Test conditions
- Hardness:
- Blank Control: old 267; new 267
22 mg/L: old 267-356; new:267-356 - Test temperature:
- 20 ± 2 °C
- pH:
- Blank Control: old 7.6 - 8.0 ; new 7.8 - 8.1
22 mg/L: old 7.8 - 8.1; new:7.9 - 8.1 - Dissolved oxygen:
- Blank Control: old 8.0 - 8.7 ; new 8.7 - 9.4
22 mg/L: old 8.2 - 8.5; new: 8.7 - 9.3 - Salinity:
- Deionised water with an enrichment of certain minerals was used in the test.
- Nominal and measured concentrations:
- 1 / 2.2 / 4.6 / 10 / 22 mg/L nominal
Results and discussion
Effect concentrationsopen allclose all
- Key result
- Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- ca. 1.05 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Key result
- Duration:
- 21 d
- Dose descriptor:
- LOEC
- Effect conc.:
- ca. 2.44 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Key result
- Duration:
- 21 d
- Dose descriptor:
- EC50
- Effect conc.:
- ca. 2.81 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Executive summary:
One valid experiment was performed using 5 concentrations ranging from 1.0 to 22 mg/L nominal concentration. Ten daphnia per concentration were exposed individually to the test item and the control for 21 days.
The offspring of the animals was counted three times a week. Decrease in reproduction was observed in the two highest treatments, ranging from 26 % to 98 %, compared to the control.The highest concentration showed also clear mortality (80 %).
The content of the test item in the test solutions was determined using GC/FID determination. The analysis of the test item concentrations in the treatments before and after exposition showed an acceptable stability of the test item during exposition. The geometric means of the measured concentrationsin the fresh prepared and the old solutionswere calculated. Their total mean was used for the evaluation of the biological results.
The test item was present in the solutions on day 2, but in very low concentrations, because of adsorption or ingestion onto the algae cells and daphnids. Therefore, one additional replicate per concentration without daphnids and algae were prepared for the analytical measurement. The geometric mean of day 0-2 was not used for evaluation of biological results.
The following results were determined for the test itemSynthetic Anethole 21/22:
NOEC = 1.05 mg/L
LOEC = 2.44 mg/L
EC50= 2.81 mg/L
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