Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 254-875-0 | CAS number: 40292-82-8
Endpoint summary
Administrative data
Description of key information
neodecanoyl chloride causes burns on the skin. Dispit being non irritation to the eye this implies the possible risk of severe eye damage as well
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
skin
Skin irritation was tested using an internal standard method (BASF test). This study meets scientific standards with acceptable restrictions (limited documentation).Whiterabbits were used. 2 animals were treated for 1 and for 4 hours using occlusive conditions. An application site of 2.5 x 2.5 cm was covered with the test substance. After 4 h exposure irritation scores were as follows: erythema 2 /4 edema 2/4. One hour exposure still caused scores of erythema 2 /4 and edema a1.5/4. Full thickness necrosis was observed after 1 and 4 h exposure. Neodecanoyl chloride is corrosive according to the results of the study.
eye
In a Draize study, 0.1 mL neodecanoyl chloride was applied to the eyes of three rabbits (strain not specified) (BASF, 1979b). No corneal or iridal reaction was noted in any of the animals at any of the examination intervals. Slight conjunctival reddening was noted in all rabbits 24 hrs and in one animal 48 hrs after treatment. Changes were reversible and absent on day 3 post treatment. Neodecanoyl chloride was considered not irritating
Effects on skin irritation/corrosion: corrosive
Justification for classification or non-classification
Based on the available data a classification concerning skin irritation (R34; Skin corr/irr Cat1b)
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
