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EC number: 239-594-3
CAS number: 15546-11-9
The following study has been submitted to address the neurotoxicity endpoint:EFSA (2004) Opinion of the Scientific Panel on Contaminants in the Food Chain on a request from the Commission to assess the health risks to consumers associated with exposure to organotins in foodstuffs. The EFSA Journal 1002: 1-119As the study is secondary source it has been allocated a Klimisch score of 4.
European Food Safety Authority (EFSA) in the Option of the Scientific
Panel on Contaminants in the Food Chain on request from the Commission
to assess the risks to consumers associated with exposure to organotins
in foodstuffs (2004),considered
evidence of neurotoxicity and concluded that, while there is clear-cut
evidence of neurotoxicity with regard to trimethyl tin, triethyltin and
triphenyltin, other tri- and also di-alkyltins are less or - possibly -
not neurotoxic at all. There is a lack of systematic experimental data
showing NOAELs. Dibutyltin shows the same biochemical effect (decoupling
of oxidative phosphorylation). With regard to risk assessment NOAELs
cannot be derived from the studies. It is however clear from available
studies, that any potential neurotoxicity is not the most sensitive
marker of dibutyltin toxicity.
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