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EC number: 216-676-7 | CAS number: 1638-86-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1997-09-17 to 1997-10-24
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP and guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 406 (Skin Sensitisation)
- Version / remarks:
- 1992-07-17
- Deviations:
- no
- GLP compliance:
- yes
- Type of study:
- Buehler test
- Species:
- guinea pig
- Strain:
- Dunkin-Hartley
- Sex:
- female
- Details on test animals and environmental conditions:
- TEST ANIMALS
- Source: Charles River GmbH -Wiga, Kisslegg, Germany
- Age at study initiation: young adult animals
- Weight at study initiation: 330-392 g
- Housing: 5 animals per cage, cage-type: Makrolon type IV
- Diet: Kliba Labordiät ad libitum
- Water: tap water ad libitum
- Acclimation period: 8 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C):21-25
- Humidity (%):30-70
- Photoperiod (hrs dark / hrs light):12/12 - Route:
- epicutaneous, occlusive
- Vehicle:
- olive oil
- Concentration / amount:
- 1st, 2nd and 3rd induction: test substance 25% in olive oil
Challenge and re-challenge: test substance 10 % in olive oil - Route:
- epicutaneous, occlusive
- Vehicle:
- olive oil
- Concentration / amount:
- 1st, 2nd and 3rd induction: test substance 25% in olive oil
Challenge and re-challenge: test substance 10 % in olive oil - No. of animals per dose:
- 10 (controls); 20 (test group)
- Details on study design:
- RANGE FINDING TESTS:
3 animals per test concentration, 6 hours exposure, application frequency 2 times o the same area (one apllication per week)
MAIN STUDY
A. INDUCTION EXPOSURE
- No. of exposures: 3
- Exposure period: 6 hours
- Test groups: 20 animals
- Control group: 10 animals
- Site:anterior left flank
- Frequency of applications:one application per week; days 0,7 and 14
B. CHALLENGE EXPOSURE
- No. of exposures:2
- Day(s) of challenge:a challenge was carried out 14 days after the third induction, a rechallenge one week after the challenge
- Exposure period: 6 hours
- Site: Challenge: test substance formulation: anterior right flank, vehicle: posterior right flank;
Rechallenge: test substance formulation: anterior left flank, vehicle: posterior left flank
- Concentrations: 10 % in olive oil
- Evaluation:24 and 48 h after challenge - Positive control substance(s):
- yes
- Remarks:
- Alpha-Hexylcinnamaldehyde
- Positive control results:
- Based an the results of the study under the test conditions chosen Alpha-Hexylcinnamaldehyde techn. 85% has a sensitizing effect an the skin af the guinea pig strain usecl (Pirbright White Dunkin Hartley Cr1: (hA) BR [SPF]; Charles River GmbH-Wiga, Kisslegg, Germany, in the BUEHLER Test.
- Reading:
- other: 1st challenge
- Hours after challenge:
- 24
- Group:
- test chemical
- Dose level:
- 10 %
- No. with + reactions:
- 13
- Total no. in group:
- 20
- Clinical observations:
- discrete or patchy erythema, moderate + confluent erythema, in some animals with swelling + intense erythema + swelling.
- Remarks on result:
- other: see Remark
- Remarks:
- Reading: other: 1st challenge. . Hours after challenge: 24.0. Group: test group. Dose level: 10 %. No with. + reactions: 13.0. Total no. in groups: 20.0. Clinical observations: discrete or patchy erythema, moderate + confluent erythema, in some animals with swelling + intense erythema + swelling. .
- Reading:
- other: 1st challenge
- Hours after challenge:
- 48
- Group:
- test chemical
- Dose level:
- 10 %
- No. with + reactions:
- 11
- Total no. in group:
- 20
- Clinical observations:
- discrete or patchy erythema, moderate and confluent erythema, in some animals with swelling.
- Remarks on result:
- other: see Remark
- Remarks:
- Reading: other: 1st challenge. . Hours after challenge: 48.0. Group: test group. Dose level: 10 %. No with. + reactions: 11.0. Total no. in groups: 20.0. Clinical observations: discrete or patchy erythema, moderate and confluent erythema, in some animals with swelling..
- Reading:
- rechallenge
- Hours after challenge:
- 24
- Group:
- test chemical
- Dose level:
- 10 %
- No. with + reactions:
- 9
- Total no. in group:
- 20
- Clinical observations:
- discrete or patchy erythema and moderate and confluent erythema
- Remarks on result:
- other: Reading: rechallenge. . Hours after challenge: 24.0. Group: test group. Dose level: 10 %. No with. + reactions: 9.0. Total no. in groups: 20.0. Clinical observations: discrete or patchy erythema and moderate and confluent erythema .
- Reading:
- rechallenge
- Hours after challenge:
- 48
- Group:
- test chemical
- Dose level:
- 10 %
- No. with + reactions:
- 11
- Total no. in group:
- 20
- Clinical observations:
- discrete or patchy erythema and moderate and confluent erythema
- Remarks on result:
- other: Reading: rechallenge. . Hours after challenge: 48.0. Group: test group. Dose level: 10 %. No with. + reactions: 11.0. Total no. in groups: 20.0. Clinical observations: discrete or patchy erythema and moderate and confluent erythema.
- Reading:
- other: 1st challenge
- Hours after challenge:
- 24
- Group:
- negative control
- Dose level:
- 0 %
- No. with + reactions:
- 0
- Total no. in group:
- 10
- Clinical observations:
- 1 animal reacted to the vehicle alone
- Remarks on result:
- other: Reading: other: 1st challenge. . Hours after challenge: 24.0. Group: negative control. Dose level: 0 %. No with. + reactions: 0.0. Total no. in groups: 10.0. Clinical observations: 1 animal reacted to the vehicle alone.
- Reading:
- other: 1st challenge
- Hours after challenge:
- 48
- Group:
- negative control
- Dose level:
- 0 %
- No. with + reactions:
- 0
- Total no. in group:
- 10
- Clinical observations:
- 2 animals reacted to the vehicle alone
- Remarks on result:
- other: Reading: other: 1st challenge. . Hours after challenge: 48.0. Group: negative control. Dose level: 0 %. No with. + reactions: 0.0. Total no. in groups: 10.0. Clinical observations: 2 animals reacted to the vehicle alone.
- Reading:
- rechallenge
- Hours after challenge:
- 24
- Group:
- negative control
- Dose level:
- 0 %
- No. with + reactions:
- 1
- Total no. in group:
- 10
- Clinical observations:
- No reactions to the vehicle alone were observed.
- Remarks on result:
- other: Reading: rechallenge. . Hours after challenge: 24.0. Group: negative control. Dose level: 0 %. No with. + reactions: 1.0. Total no. in groups: 10.0. Clinical observations: No reactions to the vehicle alone were observed..
- Reading:
- rechallenge
- Hours after challenge:
- 48
- Group:
- negative control
- Dose level:
- 0 %
- No. with + reactions:
- 1
- Total no. in group:
- 10
- Clinical observations:
- No reactions to the vehicle alone were observed.
- Remarks on result:
- other: Reading: rechallenge. . Hours after challenge: 48.0. Group: negative control. Dose level: 0 %. No with. + reactions: 1.0. Total no. in groups: 10.0. Clinical observations: No reactions to the vehicle alone were observed..
- Interpretation of results:
- sensitising
- Remarks:
- Migrated information
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
The substance Diethoxyphenylphosphin was tested for its sensitizing effect on the skin of the guinea pig in the BUEHLER Test based on the method af BUEHLER, E.V. (1965) and according to OECD 406 (BASF 1998).
The lowest minimal irritant dose used for the three inductions was 25%. Erythema and in some cases swelling were observed after the second and third induction in control and test animals. As also determined in a pretest, the highest non-irritant concentration was 10%, which was used for two challenges performed 14 and 21 days after the last induction.
1 of 10 control animals reacted to the rechallenge, but not during challenge, with the test substance. In the test group, 13 of 20 animals showed a positive reaction after 24h after the challenge application. After 48h, a positive skin reaction was observed in 11 animals. Rechallenge led to skin reactions in 9 animals after 24h and in 11 animals after 48h. Based an the results of this study it was concluded that Diethoxyphenylphosphin has a sensitizing effect on the skin of the guinea pig in the BUEHLER Test under the test conditions chosen.
Migrated from Short description of key information:
BUEHLER Test: positive (GLP, OECD 406, BASF 1998)
Justification for selection of skin sensitisation endpoint:
only one reliable GLP and guideline study available
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
The results of the BUEHLER Test show that Diethoxypheriylphosphin has a sensitizing effect on the skin of the guinea pig. According to Regulation (EC) No 1272/2008 (CLP), the test substance has to be classified into category 1B, H317 ( May cause an allergic skin reaction).
According to Directive 67/548/EEC (DSD), the substance has to be classified as Xi, R43 (May cause sensitisation by skin contact).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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