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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP and guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1988
Report date:
1998

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
EU Method B.1 (Acute Toxicity (Oral))
Version / remarks:
1992-12-29
Deviations:
no
GLP compliance:
yes
Test type:
acute toxic class method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Diethyl phenylphosphonite
EC Number:
216-676-7
EC Name:
Diethyl phenylphosphonite
Cas Number:
1638-86-4
Molecular formula:
C10H15O2P
IUPAC Name:
diethyl phenylphosphonite
Test material form:
other: liquid
Details on test material:
- Name of test material (as cited in study report): Diethoxyphenlyphosphin- DEOPP
- Physical state: liquid, colourless
- Analytical purity: 98.4 g/100g (GC)
- Lot/batch No.: 96-1008-9-HL
- Date of manufacturing: 1996-07-11
- Storage condition of test material: room temperature, exclusion of moisture, light and oxygen (store under nitrogen)

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: Dr. K. Thomas GmbH, Biberach, FRG
- Age at study initiation: young adult animals
- Weight at study initiation: 150 g - 300 g (+/- 20% of the mean weight)
- Fasting period before study: 16 h
- Housing: single housing
- Diet: Kliba-Labordiät 343, Klingentalmuehle AG Kaiseraugst.,Switzerland, ad libitum
- Water: tap water ad libitum
- Acclimation period: at least one week

ENVIRONMENTAL CONDITIONS
- Temperature (°C):20-24
- Humidity (%):30-70
- Photoperiod (hrs dark / hrs light): 12/12

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
olive oil
Details on oral exposure:
VEHICLE
- Concentration in vehicle: 10 and 40 g /100mL

CLASS METHOD
- Rationale for the selection of the starting dose: based on the physical and chemical characteristics of the substance and the composition a starting dose of 500 mg/kg body weight has been chosen with 3 male and 3 female animals. As no mortality ocured, 2000 mg/kg body weight were tested with 3 male and 3 female rats.
Doses:
500 and 2000 mg/kg bw
No. of animals per sex per dose:
3
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: weighing shortly before application (day 0), weekly thereafter and at the end of the study, recording of signs and symptoms severals times on the day of administration, at least once each workday for the individual animals
- Necropsy of survivors performed: yes

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Based on:
test mat.
Mortality:
None
Clinical signs:
other: One female animal of the high dose group: impaired general state, dyspnea, apathy, abdominal position, staggering, ataxia. The animal appeared normal one day after administration
Gross pathology:
Nothing abnormal detected

Applicant's summary and conclusion

Interpretation of results:
practically nontoxic
Remarks:
Migrated information