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EC number: 241-866-1 | CAS number: 17927-72-9
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
Data source
Reference
- Reference Type:
- other: study report
- Title:
- INITlALSUBMlSSION: LTR FR DUPONT TO USEPA SUMMARY RESULTS OF ACUTE ORAL TOXICITY & EYE IRRITATION STUDIES ON bis(pentane-2,4-dionato-O,O')bis(propan-2-olato)titanium.
- Author:
- DUPONT
- Year:
- 2 002
- Bibliographic source:
- U.S. Environmental Protection Agency
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Eye irritation study in rabbits.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Bis(pentane-2,4-dionato-O,O')bis(propan-2-olato)titanium
- EC Number:
- 241-866-1
- EC Name:
- Bis(pentane-2,4-dionato-O,O')bis(propan-2-olato)titanium
- Cas Number:
- 17927-72-9
- Molecular formula:
- C16H28O6Ti
- IUPAC Name:
- bis(pentane-2,4-dionato-O,O')bis(propan-2-olato)titanium
- Test material form:
- not specified
- Details on test material:
- No other details available
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- Not available
Test system
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- 0.1 ml
- Duration of treatment / exposure:
- 72 hrs
- Observation period (in vivo):
- 7 days
- Number of animals or in vitro replicates:
- 6 rabbits
- Details on study design:
- No other details available
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- other: no data
- Time point:
- other: 72 hrs
- Score:
- 0
- Reversibility:
- not specified
- Remarks on result:
- other: mild to severe irritation
- Other effects:
- No other effects reported
Applicant's summary and conclusion
- Interpretation of results:
- irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- In the eye irritation study, six rabbits were each treated with 0.1 mL of test material and observed for 7 days after instillation. The test material produced mild to severe eye irritation by 72 hours after instillation. Irritation was still present in all rabbits 7 days after instillation.Hence the test substance is found to be irritating to eyes.
- Executive summary:
In the eye irritation study, six rabbits were each treated with 0.1 mL of test material and observed for 7 days after instillation. The test material produced mild to severe eye irritation by 72 hours after instillation. Irritation was still present in all rabbits 7 days after instillation.
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